大肠杆菌K12及其他革兰氏阴性菌中由抗性因子R - 1818所指定的β-内酰胺酶的特性
Characterization of the -lactamase specified by the resistance factor R-1818 in E. coli K12 and other Gram-negative bacteria.
作者信息
Dale J W
出版信息
Biochem J. 1971 Jul;123(4):501-5. doi: 10.1042/bj1230501.
Abstract
- The amino acid composition of the beta-lactamase from E. coli (R-1818) was determined. 2. The R-1818 beta-lactamase is inhibited by formaldehyde, hydroxylamine, sodium azide, iodoacetamide, iodine and sodium chloride. 3. The K(m) values for benzylpenicillin, ampicillin and oxacillin have been determined by using the R-factor enzyme from different host species. The same values were obtained, irrespective of the host bacterium. 4. The molecular weight of the enzyme was found to be 44600, and was the same for all host species. 5. The relationship of R-1818 and R-GN238 beta-lactamases is discussed.
摘要
- 测定了来自大肠杆菌（R - 1818）的β - 内酰胺酶的氨基酸组成。2. R - 1818β - 内酰胺酶受到甲醛、羟胺、叠氮化钠、碘乙酰胺、碘和氯化钠的抑制。3. 通过使用来自不同宿主菌的R因子酶，测定了苄青霉素、氨苄青霉素和苯唑西林的K(m)值。无论宿主细菌如何，得到的数值相同。4. 发现该酶的分子量为44600，且所有宿主菌的该酶分子量相同。5. 讨论了R - 1818和R - GN238β - 内酰胺酶之间的关系。
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