R因子介导的可水解苯唑西林的β-内酰胺酶：两个不同组别的证据。
R-factor-mediated beta-lactamases that hydrolyze oxacillin: evidence for two distinct groups.
作者信息
Dale J W, Smith J T
出版信息
J Bacteriol. 1974 Aug;119(2):351-6. doi: 10.1128/jb.119.2.351-356.1974.
Abstract
The enzymatic and molecular properties of 14 oxacillin-hydrolyzing beta-lactamases, all of them R-factor-specified, were studied, and two distinct groups were found. Four of the enzymes had a molecular weight of 24,000, were active against methicillin, and had an electrophoretic mobility of -0.1 cm/h. Eight enzymes had a molecular weight of 45,000, low activity against methicillin, and an electrophoretic mobility of +0.5 cm/h. The remaining two enzymes were similar to those of the second group in being relatively inactive against methicillin, but their molecular weight was lower (42,000) and their electrophoretic mobility was different (-0.1 cm/h). All the enzymes of both groups were sensitive to inhibition by sodium chloride. The two groups were not completely homogeneous in their enzymatic properties; seven possible subtypes could be recognized.
摘要
对14种均由R因子编码的水解苯唑西林的β-内酰胺酶的酶学和分子特性进行了研究，发现了两个不同的组。其中四种酶的分子量为24000，对甲氧西林有活性，电泳迁移率为-0.1 cm/h。八种酶的分子量为45000，对甲氧西林活性低，电泳迁移率为+0.5 cm/h。其余两种酶与第二组酶相似，对甲氧西林相对无活性，但分子量较低（42000），电泳迁移率不同（-0.1 cm/h）。两组所有的酶都对氯化钠抑制敏感。两组在酶学特性上并非完全同质；可识别出七种可能的亚型。
相似文献
1
R-factor-mediated beta-lactamases that hydrolyze oxacillin: evidence for two distinct groups.R因子介导的可水解苯唑西林的β-内酰胺酶：两个不同组别的证据。
J Bacteriol. 1974 Aug;119(2):351-6. doi: 10.1128/jb.119.2.351-356.1974.
2
Molecular specificities of R factor-determined beta-lactamases: correlation with plasmid compatibility.R因子决定的β-内酰胺酶的分子特异性：与质粒相容性的相关性。
J Bacteriol. 1974 Jan;117(1):56-62. doi: 10.1128/jb.117.1.56-62.1974.
3
Characterization of the -lactamase specified by the resistance factor R-1818 in E. coli K12 and other Gram-negative bacteria.大肠杆菌K12及其他革兰氏阴性菌中由抗性因子R - 1818所指定的β-内酰胺酶的特性
Biochem J. 1971 Jul;123(4):501-5. doi: 10.1042/bj1230501.
4
Inhibition of R-factor-mediated beta-lactamase by Proteus mirabilis.奇异变形杆菌对R因子介导的β-内酰胺酶的抑制作用。
Antonie Van Leeuwenhoek. 1974;40(2):193-207. doi: 10.1007/BF00394377.
5
Effect of beta-lactamase location in Escherichia coli on penicillin synergy.β-内酰胺酶在大肠杆菌中的位置对青霉素协同作用的影响。
Appl Microbiol. 1969 Jun;17(6):783-6. doi: 10.1128/am.17.6.783-786.1969.
6
Interaction between carbenicillin and beta-lactamases from Gram-negative bacteria.羧苄青霉素与革兰氏阴性菌β-内酰胺酶之间的相互作用。
J Gen Microbiol. 1971 Nov;68(3):263-72. doi: 10.1099/00221287-68-3-263.
7
Effect of growth phase of host bacteria on synthesis of R factor-mediated penicillinase.宿主细菌生长阶段对R因子介导的青霉素酶合成的影响。
Jpn J Microbiol. 1974 Sep;18(5):407-10. doi: 10.1111/j.1348-0421.1974.tb00827.x.
8
Relation of R factor and chromosomal beta-lactamase with the periplasmic space.R 因子和染色体β-内酰胺酶与周质空间的关系。
J Bacteriol. 1974 Mar;117(3):931-9. doi: 10.1128/jb.117.3.931-939.1974.
9
Some relationships between R-factor and chromosomal -lactamase in Gram-negative bacteria.革兰氏阴性菌中R因子与染色体β-内酰胺酶之间的一些关系。
Biochem J. 1971 Jul;123(4):507-12. doi: 10.1042/bj1230507.
10
The nature of resistance to penicillins mediated by R-factor.
Arch Immunol Ther Exp (Warsz). 1969;17(5):633-8.
引用本文的文献
1
Acquired Class D β-Lactamases.获得性 D 类 β-内酰胺酶。
Antibiotics (Basel). 2014 Aug 21;3(3):398-434. doi: 10.3390/antibiotics3030398.
2
Characterization of a Carbapenem-Hydrolyzing Enzyme, PoxB, in Pseudomonas aeruginosa PAO1.铜绿假单胞菌PAO1中碳青霉烯水解酶PoxB的特性分析
Antimicrob Agents Chemother. 2015 Nov 30;60(2):936-45. doi: 10.1128/AAC.01807-15. Print 2016 Feb.
3
OXA β-lactamases.OXA β-内酰胺酶
Clin Microbiol Rev. 2014 Apr;27(2):241-63. doi: 10.1128/CMR.00117-13.
4
Substrate-induced inactivation of the OXA2 beta-lactamase.底物诱导的OXA2β-内酰胺酶失活
Biochem J. 1993 Nov 1;295 ( Pt 3)(Pt 3):871-8. doi: 10.1042/bj2950871.
5
Comparative activities of clavulanic acid, sulbactam, and tazobactam against clinically important beta-lactamases.棒酸、舒巴坦和他唑巴坦对临床重要β-内酰胺酶的比较活性。
Antimicrob Agents Chemother. 1994 Apr;38(4):767-72. doi: 10.1128/AAC.38.4.767.
6
Development of test panel of beta-lactamases expressed in a common Escherichia coli host background for evaluation of new beta-lactam antibiotics.在常见大肠杆菌宿主背景中表达的β-内酰胺酶检测板的开发，用于评估新型β-内酰胺类抗生素。
Antimicrob Agents Chemother. 1995 Feb;39(2):308-13. doi: 10.1128/AAC.39.2.308.
7
A functional classification scheme for beta-lactamases and its correlation with molecular structure.β-内酰胺酶的功能分类方案及其与分子结构的相关性。
Antimicrob Agents Chemother. 1995 Jun;39(6):1211-33. doi: 10.1128/AAC.39.6.1211.
8
Antibiotic resistance in pathogenic and producing bacteria, with special reference to beta-lactam antibiotics.致病细菌和产抗生素细菌中的抗生素耐药性，特别提及β-内酰胺类抗生素。
Microbiol Rev. 1981 Dec;45(4):591-619. doi: 10.1128/mr.45.4.591-619.1981.
9
Principal beta-lactamases responsible for resistance to beta-lactam antibiotics in urinary tract infections.导致尿路感染对β-内酰胺类抗生素耐药的主要β-内酰胺酶。
Antimicrob Agents Chemother. 1980 Jun;17(6):929-36. doi: 10.1128/AAC.17.6.929.
10
Properties of a new penicillinase type produced by Bacteroides fragilis.脆弱拟杆菌产生的一种新型青霉素酶的特性
Antimicrob Agents Chemother. 1982 Oct;22(4):579-84. doi: 10.1128/AAC.22.4.579.
本文引用的文献
1
RESISTANCE TO PENICILLINS AND ITS TRANSFER IN ENTEROBACTERIACEAE.肠杆菌科细菌对青霉素的耐药性及其转移
Lancet. 1965 Feb 20;1(7382):407-9. doi: 10.1016/s0140-6736(65)90004-8.
2
Use of cellulose acetate membranes for detecting penicillinase-producing organisms.使用醋酸纤维素膜检测产青霉素酶的微生物。
Nature. 1961 Aug 26;191:926-7. doi: 10.1038/191926a0.
3
Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults.淀粉凝胶区带电泳：正常成年人血清蛋白的群体差异
Biochem J. 1955 Dec;61(4):629-41. doi: 10.1042/bj0610629.
4
Cell-bound penicillinase of Bacillus licheniformis; properties and purification.地衣芽孢杆菌的细胞结合青霉素酶；性质与纯化
J Gen Microbiol. 1967 Aug;48(2):249-59. doi: 10.1099/00221287-48-2-249.
5
Purification and properties of glutathione reductase of human erythrocytes.人红细胞谷胱甘肽还原酶的纯化及性质
Biochim Biophys Acta. 1969 Jul 8;185(1):39-48. doi: 10.1016/0005-2744(69)90280-0.
6
Separation of blood coagulation factors II, VII, IX and X by gel filtration in the presence of dextran blue.
Biochim Biophys Acta. 1970 Dec 29;222(3):692-5. doi: 10.1016/0304-4165(70)90203-5.
7
-lactamases of R factors derived from Shigella and Salmonella strains.源自志贺氏菌和沙门氏菌菌株的R因子的β-内酰胺酶
J Bacteriol. 1971 Oct;108(1):159-65. doi: 10.1128/jb.108.1.159-165.1971.
8
The purification and properties of penicillin beta-lactamases mediated by transmissible R factors in Escherichia coli.大肠杆菌中由可传递R因子介导的青霉素β-内酰胺酶的纯化及特性
J Biochem. 1969 Jul;66(1):11-20. doi: 10.1093/oxfordjournals.jbchem.a129111.
9
Beta-lactamase of R factors.R 因子的β-内酰胺酶
J Bacteriol. 1968 Oct;96(4):1441-2. doi: 10.1128/jb.96.4.1441-1442.1968.
10
Some relationships between R-factor and chromosomal -lactamase in Gram-negative bacteria.革兰氏阴性菌中R因子与染色体β-内酰胺酶之间的一些关系。
Biochem J. 1971 Jul;123(4):507-12. doi: 10.1042/bj1230507.
Zotero 插件