派尔集合淋巴结淋巴细胞的功能特性。I. 体液抗体的诱导及细胞介导的同种异体移植反应。

Functional characteristics of Peyer's patch lymphoid cells. I. Induction of humoral antibody and cell-mediated allograft reactions.

作者信息

Kagnoff M F, Campbell S

出版信息

J Exp Med. 1974 Feb 1;139(2):398-406. doi: 10.1084/jem.139.2.398.

DOI:10.1084/jem.139.2.398

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2139531/

Abstract

Peyer's patches from normal mice contain antigen-sensitive B and T cells, but lack the accessory adherent cell type(s) required both for the induction of humoral immune responses and for the induction of allograft reactions against cell surface alloantigens. Immune responsiveness can be restored to cultures of Peyer's patch cells by the addition of either APEC or ME. Peyer's patch B cells can be specifically induced by antigen to synthesize humoral antibody. Peyer's patch T cells can cooperate in B-cell induction and can be induced to mediate an allograft reaction against an allogeneic stimulus. Peyer's patch lymphoid aggregates appear to be a storehouse of antigen-sensitive cells sequestered in such a way as to lack an accessory cell type or factor required for induction,

摘要

正常小鼠的派尔集合淋巴结含有对抗抗原的B细胞和T细胞，但缺乏诱导体液免疫反应以及诱导针对细胞表面同种异体抗原的移植排斥反应所需的辅助黏附细胞类型。通过添加APEC或ME，可恢复派尔集合淋巴结细胞培养物的免疫反应性。派尔集合淋巴结B细胞可被抗原特异性诱导以合成体液抗体。派尔集合淋巴结T细胞可在B细胞诱导中发挥协同作用，并可被诱导介导针对同种异体刺激的移植排斥反应。派尔集合淋巴结淋巴集结似乎是一个抗原敏感细胞的储存库，其隔离方式使其缺乏诱导所需的辅助细胞类型或因子。

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