Chipps B E, Saulsbury F T, Hsu S H, Hughes W T, Winkelstein J A
Johns Hopkins Med J. 1979 Jun;144(6):175-9.
Chronic mucocutaneous candidiasis (CMCC) is a clinical syndrome characterized by persistent and recurrent Candida albicans infections of the mucous membranes and skin often associated with immunodeficiency. In order to gain insight into the frequency and severity of non-candidal infections in children with CMCC, four patients with CMCC are described in detail and 60 previously reported cases are reviewed. Fifty percent of children with CMCC had significant infections with other fungi, bacteria and viruses. Recurrent bacterial pneumonias and bronchiectasis were a major cause of morbidity and mortality. In addition, there were a large number of infections, in both the lung and other sites, due to opportunistic organisms. Thus the clincial syndrome of CMCC includes not only mucocutaneous candidiasis, endocrine failure and autoimmune phenomena, but patients with CMCC also show a remarkable susceptibility to non-candidal infections. These non-candidal infections represent a serious cause of morbidity for patients with CMCC.
慢性黏膜皮肤念珠菌病（CMCC）是一种临床综合征，其特征为黏膜和皮肤持续且反复的白色念珠菌感染，常与免疫缺陷相关。为深入了解CMCC患儿非念珠菌感染的频率和严重程度，详细描述了4例CMCC患儿，并对60例既往报道的病例进行了回顾。50%的CMCC患儿发生了其他真菌、细菌和病毒的严重感染。复发性细菌性肺炎和支气管扩张是发病和死亡的主要原因。此外，肺部和其他部位还存在大量由机会性病原体引起的感染。因此，CMCC的临床综合征不仅包括黏膜皮肤念珠菌病、内分泌衰竭和自身免疫现象，CMCC患者对非念珠菌感染也表现出显著的易感性。这些非念珠菌感染是CMCC患者发病的严重原因。
