巯基结合化合物的杀菌作用。
Bactericidal action of sulfhydryl binding compounds.
作者信息
Tuli V
出版信息
Antimicrob Agents Chemother. 1973 Feb;3(2):157-61. doi: 10.1128/AAC.3.2.157.
Abstract
An oxidation product of indole-3-acetic acid, 3-methyleneoxindole, is highly reactive with free sulfhydryl groups. It has been shown to be a potent bactericidal agent in actively growing cultures. The bactericidal action of 3-methyleneoxindole was found to be independent of protein or deoxyribonucleic acid synthesis but to require the capacity for ribonucleic acid synthesis. The reactions underlying the bactericidal effect of 3-methyleneoxindole are not unique to it among compounds which can bind free SH groups, since N-ethylmaleimide appeared to have a similar mode of action.
摘要
吲哚-3-乙酸的一种氧化产物3-亚甲基氧化吲哚与游离巯基具有高度反应性。已证明它在活跃生长的培养物中是一种有效的杀菌剂。发现3-亚甲基氧化吲哚的杀菌作用与蛋白质或脱氧核糖核酸的合成无关，但需要核糖核酸的合成能力。在能够结合游离SH基团的化合物中，3-亚甲基氧化吲哚杀菌作用背后的反应并非其独有的，因为N-乙基马来酰亚胺似乎具有类似的作用方式。
相似文献
1
Bactericidal action of sulfhydryl binding compounds.巯基结合化合物的杀菌作用。
Antimicrob Agents Chemother. 1973 Feb;3(2):157-61. doi: 10.1128/AAC.3.2.157.
2
Some biological effects of carbamoyloxyurea, an oxidation product of hydroxyurea.羟基脲的氧化产物氨甲酰氧基脲的一些生物学效应。
J Bacteriol. 1970 Apr;102(1):20-3. doi: 10.1128/jb.102.1.20-23.1970.
3
Mechanism of action of nalidixic acid on Escherichia coli. 3. Conditions required for lethality.萘啶酸对大肠杆菌的作用机制。3. 致死所需条件。
J Bacteriol. 1966 Feb;91(2):768-73. doi: 10.1128/jb.91.2.768-773.1966.
4
Effects of mitomycin C on macromolecular synthesis in Escherichia coli.丝裂霉素C对大肠杆菌中大分子合成的影响。
J Bacteriol. 1967 Feb;93(2):675-82. doi: 10.1128/jb.93.2.675-682.1967.
5
Bactericidal effect against Escherichia coli of nalidixic acid and four structurally related compounds.萘啶酸及四种结构相关化合物对大肠杆菌的杀菌作用。
J Antimicrob Chemother. 1980 Jul;6(4):535-42. doi: 10.1093/jac/6.4.535.
6
Selective inhibition of f2 RNA translation by sulfhydryl reagents.巯基试剂对f2 RNA翻译的选择性抑制作用。
Arch Biochem Biophys. 1973 Sep;158(1):257-65. doi: 10.1016/0003-9861(73)90620-6.
7
Action of phyenethyl alcohol on the synthesis of macromolecules in Escherichia coli.苯乙醇对大肠杆菌中大分子合成的作用。
J Bacteriol. 1966 Apr;91(4):1446-52. doi: 10.1128/jb.91.4.1446-1452.1966.
8
Requirement for ribonucleic acid synthesis for deoxyribonucleic acid replication in bacteria.细菌中脱氧核糖核酸复制对核糖核酸合成的需求。
Nature. 1966 Jul 2;211(5044):39-41. doi: 10.1038/211039a0.
9
Inhibition of Escherichia coli by thioglycerol.硫代甘油对大肠杆菌的抑制作用。
Antimicrob Agents Chemother. 1981 Apr;19(4):556-61. doi: 10.1128/AAC.19.4.556.
10
Correlation of quinolone MIC and inhibition of DNA, RNA, and protein synthesis and induction of the SOS response in Escherichia coli.喹诺酮类药物对大肠杆菌的最低抑菌浓度（MIC）与DNA、RNA和蛋白质合成抑制及SOS反应诱导之间的相关性。
Antimicrob Agents Chemother. 1990 Dec;34(12):2331-6. doi: 10.1128/AAC.34.12.2331.
引用本文的文献
1
Antiviral activity of 3-methyleneoxindole.3-亚甲基氧化吲哚的抗病毒活性
Antimicrob Agents Chemother. 1974 May;5(5):479-84. doi: 10.1128/AAC.5.5.479.
2
Mechanism of the antiviral action of 3-methyleneoxindole.3-亚甲基氧化吲哚的抗病毒作用机制。
Antimicrob Agents Chemother. 1974 May;5(5):485-91. doi: 10.1128/AAC.5.5.485.
本文引用的文献
1
Inhibitory oxidation products of indole-3-acetic Acid: 3-hydroxymethyloxindole and 3-methyleneoxindole as plant metabolites.吲哚-3-乙酸的抑制性氧化产物：3-羟甲基吲哚酮和3-亚甲基吲哚酮作为植物代谢物。
Plant Physiol. 1967 Mar;42(3):425-30. doi: 10.1104/pp.42.3.425.
2
Nucleic acid metabolism in relation to the lysogenic phenomenon.与溶原现象相关的核酸代谢
J Bacteriol. 1955 Apr;69(4):460-7. doi: 10.1128/jb.69.4.460-467.1955.
3
INHIBITORY OXIDATION PRODUCTS OF INDOLE-3-ACETIC ACID. MECHANISM OF ACTION AND ROUTE OF DETOXIFICATION.吲哚-3-乙酸的抑制性氧化产物。作用机制与解毒途径。
J Biol Chem. 1965 Jun;240:2612-8.
4
INHIBITION OF CELL GROWTH BY PHOTOOXIDATION PRODUCTS OF INDOLE-3-ACETIC ACID.吲哚-3-乙酸光氧化产物对细胞生长的抑制作用
J Biol Chem. 1964 Jul;239:2392-7.
5
Mode of action of chloramphenicol. I. Action of chloramphenicol on assimilation of ammonia and on synthesis of proteins and nucleic acids in Escherichia coli.氯霉素的作用方式。I. 氯霉素对大肠杆菌中氨同化以及蛋白质和核酸合成的作用。
J Bacteriol. 1954 Jun;67(6):662-73. doi: 10.1128/jb.67.6.662-673.1954.
6
The assimilation of amino-acids by bacteria. XV. Actions of antibiotics on nucleic acid and protein synthesis in Staphylococcus aureus.细菌对氨基酸的同化作用。十五。抗生素对金黄色葡萄球菌核酸和蛋白质合成的作用。
Biochem J. 1953 Feb;53(3):493-8. doi: 10.1042/bj0530493.
7
The role of 3-methyleneoxindole in auxin action.3-亚甲基氧化吲哚在生长素作用中的作用。
J Biol Chem. 1969 Sep 25;244(18):4916-20.
8
Desensitization of regulatory enzymes by a metabolite of plant auxin.植物生长素的一种代谢产物对调节酶的脱敏作用。
J Biol Chem. 1966 Oct 10;241(19):4564-6.
9
Studies with hydroxyurea. I. The reversible inhibition of bacterial DNA synthesis and the effect of hydroxyurea on the bactericidal action of streptomycin.羟基脲的研究。I. 细菌DNA合成的可逆抑制以及羟基脲对链霉素杀菌作用的影响。
Biochim Biophys Acta. 1966 Mar 21;114(3):501-15.
10
Physiology and genetics of the "ribonucleic acid control" locus in escherichia coli.大肠杆菌中“核糖核酸控制”位点的生理学与遗传学
Bacteriol Rev. 1968 Sep;32(3):206-26. doi: 10.1128/br.32.3.206-226.1968.
Zotero 插件