巯基结合化合物的杀菌作用。
Bactericidal action of sulfhydryl binding compounds.
作者信息
Tuli V
出版信息
Antimicrob Agents Chemother. 1973 Feb;3(2):157-61. doi: 10.1128/AAC.3.2.157.
Abstract
An oxidation product of indole-3-acetic acid, 3-methyleneoxindole, is highly reactive with free sulfhydryl groups. It has been shown to be a potent bactericidal agent in actively growing cultures. The bactericidal action of 3-methyleneoxindole was found to be independent of protein or deoxyribonucleic acid synthesis but to require the capacity for ribonucleic acid synthesis. The reactions underlying the bactericidal effect of 3-methyleneoxindole are not unique to it among compounds which can bind free SH groups, since N-ethylmaleimide appeared to have a similar mode of action.
摘要
吲哚-3-乙酸的一种氧化产物3-亚甲基氧化吲哚与游离巯基具有高度反应性。已证明它在活跃生长的培养物中是一种有效的杀菌剂。发现3-亚甲基氧化吲哚的杀菌作用与蛋白质或脱氧核糖核酸的合成无关，但需要核糖核酸的合成能力。在能够结合游离SH基团的化合物中，3-亚甲基氧化吲哚杀菌作用背后的反应并非其独有的，因为N-乙基马来酰亚胺似乎具有类似的作用方式。
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