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小鼠肠道与本地微生物群落成员之间的抗原交叉反应。

Antigenic cross-reaction between mouse intestine and a member of the autochthonous microflora.

作者信息

Foo M C, Lee A

出版信息

Infect Immun. 1974 Jun;9(6):1066-9. doi: 10.1128/iai.9.6.1066-1069.1974.

DOI:10.1128/iai.9.6.1066-1069.1974
PMID:4598254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC414934/
Abstract

Antigenic cross-reaction has been demonstrated between homogenates of intestine taken from fetal mice and suspensions of a Bacteriodes species isolated from the large intestines of normal adult mice. This observation provides an explanation for the lack of immunological response observed in mice after antigenic stimulation with this member of the normal autochthonous intestinal flora of these animals.

摘要

已证实取自胎鼠的肠道匀浆与从正常成年小鼠大肠分离出的一种拟杆菌属细菌的悬液之间存在抗原交叉反应。这一观察结果解释了在用这些动物正常肠道固有菌群的该成员进行抗原刺激后，小鼠中未观察到免疫反应的原因。

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本文引用的文献

1
Mechanism of Action of Intestinal Antibody in Experimental Cholera II. Antibody-Mediated Antibacterial Reaction at the Mucosal Surface.肠抗体在实验性霍乱中的作用机制 II. 黏膜表面的抗体介导的抗菌反应。
Infect Immun. 1970 Nov;2(5):556-62. doi: 10.1128/iai.2.5.556-562.1970.
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THE DEVELOPMENT OF THE BACTERIAL FLORA IN THE GASTROINTESTINAL TRACT OF MICE.小鼠胃肠道中细菌菌群的发育
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Host responses to "normal" microbial flora in germ-free mice.
J Reticuloendothel Soc. 1971 Jun;9(6):580-7.
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Localization of bacteria in the gastrointestinal tract: a possible explanation of intestinal spirochaetosis.胃肠道中细菌的定位：肠道螺旋体病的一种可能解释。
Infect Immun. 1973 Jun;7(6):961-72. doi: 10.1128/iai.7.6.961-972.1973.
5
Immunological response of mice to members of the autochthonous intestinal microflora.小鼠对本地肠道微生物群落成员的免疫反应。
Infect Immun. 1972 Oct;6(4):525-32. doi: 10.1128/iai.6.4.525-532.1972.
6
Location and description of spiral-shaped microorganisms in the normal rat cecum.正常大鼠盲肠中螺旋形微生物的位置及描述。
Infect Immun. 1972 Aug;6(2):184-92. doi: 10.1128/iai.6.2.184-192.1972.