Apperloo-Renkema H Z, Jagt T G, Tonk R H, van der Waaij D
Laboratory for Medical Microbiology, State University of Groningen, The Netherlands.
Epidemiol Infect. 1993 Oct;111(2):273-85. doi: 10.1017/s0950268800056983.
Healthy persons were shown to possess circulating antibodies of both IgA, IgG and IgM isotype directed against the bacteria of their faecal microflora, assessed by immunomorphometry. After removal, by absorption, of the fraction of antibodies directed against the autochthonous faecal bacteria or cross-reacting with allogenous faecal bacteria, there were still antibodies left directed against allogenous faecal bacteria of both the IgA, IgG and IgM isotype. However, relatively more antibodies of the IgA isotype appeared to be directed against allogenous bacteria than against indigenous faecal bacteria. Persons who reacted with specific antibodies to many bacteria of their own flora also tended to react specifically to bacteria in the allogenous microflora of the other volunteers. The patterns of antibodies directed to faecal bacteria of different morphologies (morphotypes) were unique for each individual.
通过免疫形态测定法评估发现，健康人血液中存在针对其粪便微生物群细菌的IgA、IgG和IgM同型循环抗体。通过吸收去除针对自身粪便细菌或与异体粪便细菌交叉反应的抗体部分后，仍存在针对异体粪便细菌的IgA、IgG和IgM同型抗体。然而，与针对自身粪便细菌的抗体相比，相对更多的IgA同型抗体似乎是针对异体细菌的。对自身菌群中许多细菌产生特异性抗体反应的人，也往往对其他志愿者异体微生物群中的细菌产生特异性反应。针对不同形态（形态型）粪便细菌的抗体模式对每个人来说都是独特的。
