Slocombe B, Sutherland R
Antimicrob Agents Chemother. 1973 Oct;4(4):459-66. doi: 10.1128/AAC.4.4.459.
Enteropathogenic strains of Escherichia coli which had been isolated in the United Kingdom during three periods between 1948 and 1968, namely 1948 to 1951, 1957 to 1960, and 1967 to 1968, were tested for susceptibility to ampicillin, streptomycin, tetracycline, chloramphenicol, and sulphonamides. Antibiotic-resistant strains were tested for their ability to transfer antibiotic resistance to an antibiotic-susceptible strain of E. coli K-12. A relatively high proportion of strains isolated between 1948 and 1951 was resistant to ampicillin, streptomycin, or sulphonamides. None of these strains transferred ampicillin or streptomycin resistance, but sulphonamide resistance was R-factor-mediated in three out of 14 sulphonamide-resistant strains. Resistance to tetracycline and chloramphenicol was rare before 1951 but had become common among enteropathogenic E. coli by 1957. Much of the antibiotic resistance of bacteria isolated between 1957 and 1960 was R-factor-mediated, and transferable resistance was about as prevalent among E. coli isolated between 1957 and 1960 as among strains isolated in 1967 and 1968. Nevertheless, there was no appreciable increase in the overall incidence of antibiotic resistance among these enteropathogenic strains of E. coli between 1957 and 1968, although transferable antibiotic resistance was common during this period. These results do not suggest that the emergence of transferable antibiotic resistance will inevitably lead to the rapid development of antibiotic resistance among this group of bacteria.
对1948年至1968年间英国三个时间段（即1948年至1951年、1957年至1960年以及1967年至1968年）分离出的致病性大肠杆菌菌株进行了氨苄西林、链霉素、四环素、氯霉素和磺胺类药物的敏感性测试。对耐药菌株测试了它们将抗生素耐药性转移至大肠杆菌K - 12敏感菌株的能力。1948年至1951年间分离出的菌株中，相对较高比例的菌株对氨苄西林、链霉素或磺胺类药物耐药。这些菌株中没有一个能转移氨苄西林或链霉素耐药性，但在14株磺胺类药物耐药菌株中有3株的磺胺类药物耐药性是由R因子介导的。1951年之前对四环素和氯霉素的耐药性很少见，但到1957年在致病性大肠杆菌中已变得普遍。1957年至1960年间分离出的细菌的大部分抗生素耐药性是由R因子介导的，1957年至1960年间分离出的大肠杆菌中可转移耐药性的普遍程度与1967年至1968年间分离出的菌株相当。然而，尽管在此期间可转移抗生素耐药性很常见，但在1957年至1968年间这些致病性大肠杆菌菌株中抗生素耐药性的总体发生率没有明显增加。这些结果并不表明可转移抗生素耐药性的出现将不可避免地导致这组细菌中抗生素耐药性的快速发展。
