Gross R J, Ward L R, Threlfall E J, King H, Rowe B
Br Med J (Clin Res Ed). 1982 Aug 14;285(6340):472-3. doi: 10.1136/bmj.285.6340.472.
Two hundred and thirty-two strains of Escherichia coli belonging to infantile enteropathogenic serotypes isolated in the United Kingdom during 1980 and 1981 were tested for resistance to 10 antimicrobial drugs. Resistance to one or more drugs was found in 134 (57.8%) of the strains, with resistance to sulphonamides, streptomycin, tetracycline, and ampicillin occurring most commonly. Resistance was transferable in 65 out of 104 resistant strains. These findings are a cause for concern because they indicate that the choice of treatment for severe illness is limited and suggest that a large pool of drug-resistant organisms exists in the community.
对1980年和1981年在英国分离出的232株属于婴儿肠道致病性血清型的大肠杆菌菌株进行了10种抗菌药物的耐药性测试。在134株(57.8%)菌株中发现了对一种或多种药物的耐药性,其中对磺胺类、链霉素、四环素和氨苄青霉素的耐药性最为常见。在104株耐药菌株中有65株的耐药性是可转移的。这些发现令人担忧,因为它们表明重症治疗的选择有限,也提示社区中存在大量耐药生物体。