Newbold R F, Amos J, Connell J R
Mutat Res. 1979 May;67(1):55-63. doi: 10.1016/0165-1218(79)90099-5.
Examples of chromic and chromate salts have been examined for their effects on a cultured Chinese hamster cell line. The responses studied were cytotoxicity, mutagenesis and clastogenesis. Chromate (hexavalent chromium) salts of both high and medium water solubility were active in producing all three classes of response, whereas an insoluble chromate salt and a soluble chromic (trivalent chromium) salt were inactive. In addition to illustrating the value of using mammalian cells in culture for screening chemicals for biological activity, the results of this study reinforce current views regarding the genotoxic properties of chromates.
已对多种铬酸盐和重铬酸盐进行了检测，以研究它们对一种培养的中国仓鼠细胞系的影响。所研究的反应包括细胞毒性、诱变作用和染色体断裂作用。高水溶性和中等水溶性的铬酸盐（六价铬）盐在引发所有这三类反应方面都具有活性，而一种不溶性铬酸盐和一种可溶性铬（三价铬）盐则无活性。除了说明利用培养的哺乳动物细胞来筛选具有生物活性的化学物质的价值外，本研究结果还强化了当前有关铬酸盐遗传毒性特性的观点。
