Clements J B, Sinsheimer R L
J Virol. 1974 Dec;14(6):1630-2. doi: 10.1128/JVI.14.6.1630-1632.1974.
Nonpermissive cells infected with phiX174 gene D amber mutants synthesized some sixfold less viral RNA than permissive cells. The decrease was unaffected by increasing the multiplicity of infection and was a consequence of an overall decrease in all viral RNA species. It is suggested that the gene D product may function in replicative form DNA unwinding to expose the template for transcription.
感染了φX174基因D琥珀突变体的非允许细胞合成的病毒RNA比允许细胞少约六倍。这种减少不受感染复数增加的影响,并且是所有病毒RNA种类总体减少的结果。有人提出,基因D产物可能在复制型DNA解旋以暴露转录模板的过程中发挥作用。