在tsDNA突变型大肠杆菌中对三种φX174突变体的生长研究。
Growth studies of three phi chi 174 mutants in tsDNA mutants Escherichia coli.
作者信息
Haworth S R, Gilgun C F, Dowell C E
出版信息
J Virol. 1975 Apr;15(4):720-5. doi: 10.1128/JVI.15.4.720-725.1975.
Abstract
Three mutants of phi chi 174 were examined for their abilities to grow in temperature-sensitive dna,A, dnaC, dnaE, or dnaG mutants of Escherichia coli. The results indicate that the phage mutants have acquired the ability to grow in some tsDNA mutants that normally block the replication of wild-type phi chi 174. Evidence is presented indicating that the phage mutants contain one or more altered structural proteins. Several models are presented to explain how altered phage structural proteins could affect phi chi 174 replication.
摘要
检测了φX174的三个突变体在大肠杆菌温度敏感型dnaA、dnaC、dnaE或dnaG突变体中生长的能力。结果表明，噬菌体突变体获得了在一些通常会阻断野生型φX174复制的温度敏感型dna突变体中生长的能力。有证据表明，噬菌体突变体含有一种或多种改变的结构蛋白。提出了几种模型来解释改变的噬菌体结构蛋白如何影响φX174的复制。
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