Dennis P P, Nomura M
Proc Natl Acad Sci U S A. 1974 Oct;71(10):3819-23. doi: 10.1073/pnas.71.10.3819.
The regulation of the expression of ribosomal protein genes was examined during partial inhibition of tRNA aminoacylation in isogenic rel(+) and rel(-) strains of E. coli B carrying a temperature-sensitive mutation in valyl-tRNA synthetase (EC 6.1.1.9) gene. Measurements of the differential synthesis rate of ribosomal protein, alpha(r) (ribosomal protein synthesis rate/total protein synthesis rate), indicate that ribosomal protein synthesis is regulated directly or indirectly by availability of charged tRNA, and that the synthesis of ribosomal protein, like the synthesis of rRNA, is subject to the influence of the rel gene control system.
在携带缬氨酰 - tRNA合成酶（EC 6.1.1.9）基因温度敏感突变的大肠杆菌B的同基因rel(+)和rel(-)菌株中，当tRNA氨酰化受到部分抑制时，对核糖体蛋白基因表达的调控进行了研究。核糖体蛋白α(r)（核糖体蛋白合成速率/总蛋白合成速率）差异合成速率的测量表明，核糖体蛋白的合成直接或间接受带电荷tRNA可用性的调节，并且核糖体蛋白的合成与rRNA的合成一样，受到rel基因控制系统的影响。
