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1
Protection against gram-negative infections with antiserum to lipid A from Salmonella minnesota R595.用来自明尼苏达沙门氏菌R595的脂多糖A抗血清预防革兰氏阴性菌感染。
Infect Immun. 1974 Dec;10(6):1195-201. doi: 10.1128/iai.10.6.1195-1201.1974.
2
Effect of active and passive immunizations with lipid A and salmonella minnesota Re 595 on gram-negative infections in mice.用脂质A和明尼苏达沙门氏菌Re 595进行主动和被动免疫对小鼠革兰氏阴性菌感染的影响。
Infection. 1976;4(2):5-10. doi: 10.1007/BF01638340.
3
Immunization with R mutants of S. Minnesota. I. Protection against challenge with heterologous gram-negative bacilli.用明尼苏达沙门氏菌R突变体进行免疫。I. 抵抗异源革兰氏阴性杆菌攻击的保护作用。
J Immunol. 1972 Mar;108(3):601-10.
4
Passive protection against heterologous gram-negative bacteria mediated by antiserum to epimeraseless Rc mutant of Salmonella minnesota.
Ann Immunol (Paris). 1982 Jul-Aug;133D(1):71-6.
5
Relationship of structure to function in bacterial endotoxins: serologically cross-reactive components and their effect on protection of mice against some gram-negative infections.细菌内毒素的结构与功能关系：血清学交叉反应成分及其对小鼠抵抗某些革兰氏阴性菌感染的保护作用。
J Gen Microbiol. 1976 May;94(1):107-16. doi: 10.1099/00221287-94-1-107.
6
Cross-protective immunity to Gram-negative bacilli: studies with core glycolipid of Salmonella minnesota and antigens of Streptococcus pneumoniae.对革兰氏阴性杆菌的交叉保护性免疫：用明尼苏达沙门氏菌核心糖脂和肺炎链球菌抗原进行的研究。
J Infect Dis. 1977 Aug;136 Suppl:S174-80. doi: 10.1093/infdis/136.supplement.s174.
7
The effect of antisera on porcine enteropathogenic Escherichia coli in ligated segments of pig intestine.抗血清对猪肠道结扎段中猪肠道致病性大肠杆菌的作用。
Can J Comp Med. 1975 Jan;39(1):46-53.
8
Immunization with rough mutants of Salmonella minnesota. IV. Protection by antisera to O and rough antigens against endotoxin.用明尼苏达沙门氏菌粗糙突变株进行免疫。IV. 抗O抗原和粗糙抗原血清对内毒素的保护作用。
J Infect Dis. 1983 Jan;147(1):57-67. doi: 10.1093/infdis/147.1.57.
9
Cross-reaction between the genus-specific lipopolysaccharide antigen of Chlamydia spp. and the lipopolysaccharides of Porphyromonas gingivalis, Escherichia coli O119 and Salmonella newington: implications for diagnosis.衣原体属特异性脂多糖抗原与牙龈卟啉单胞菌、大肠杆菌O119和纽因顿沙门氏菌脂多糖之间的交叉反应：对诊断的影响
Diagn Microbiol Infect Dis. 2001 Nov;41(3):99-106. doi: 10.1016/s0732-8893(01)00299-1.
10
Effect of common enterobacterial antiserum on experimental Salmonella typhimurium infection of mice.普通肠杆菌抗血清对小鼠实验性鼠伤寒沙门氏菌感染的影响。
Proc Soc Exp Biol Med. 1971 Sep;137(4):1209-12. doi: 10.3181/00379727-137-35757.

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1
Protection against avian pathogenic Escherichia coli and Salmonella Kentucky exhibited in chickens given both probiotics and live Salmonella vaccine.同时给予益生菌和活沙门氏菌疫苗可使鸡对禽致病性大肠杆菌和肯塔基沙门氏菌产生保护。
Poult Sci. 2020 Feb;99(2):752-762. doi: 10.1016/j.psj.2019.10.038. Epub 2019 Nov 28.
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The importance of anti-lipid A (anti-endotoxin): prevention of "shock lung" and acute renal failure.抗脂质A（抗内毒素）的重要性：预防“休克肺”和急性肾衰竭。
World J Surg. 1982 Sep;6(5):616-23. doi: 10.1007/BF01657880.
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Experimental Escherichia coli ascending pyelonephritis in rats: active peroral immunization with live Escherichia coli.大鼠实验性大肠杆菌上行性肾盂肾炎：用活大肠杆菌进行主动口服免疫
Infect Immun. 1982 Feb;35(2):647-53. doi: 10.1128/iai.35.2.647-653.1982.
4
Immune response to parental and rough mutant strains of Salmonella minnesota.对明尼苏达沙门氏菌亲本菌株和粗糙突变菌株的免疫反应。
Infect Immun. 1981 Sep;33(3):784-7. doi: 10.1128/iai.33.3.784-787.1981.
5
Common lipopolysaccharide specificity: new type of antigen residing in the inner core region of S- and R-form lipopolysaccharides from different families of gram-negative bacteria.常见脂多糖特异性：存在于不同革兰氏阴性菌家族的S型和R型脂多糖内核区域的新型抗原。
Infect Immun. 1983 Oct;42(1):250-6. doi: 10.1128/iai.42.1.250-256.1983.
6
Serum antibodies against common antigens of bacterial lipopolysaccharides in healthy adults and in patients with multiple myeloma.健康成年人及多发性骨髓瘤患者体内针对细菌脂多糖常见抗原的血清抗体。
Infection. 1985 May-Jun;13(3):115-9. doi: 10.1007/BF01642869.
7
The immunogenicity and antigenicity of lipid A are influenced by its physicochemical state and environment.脂质A的免疫原性和抗原性受其物理化学状态和环境的影响。
Infect Immun. 1987 Nov;55(11):2636-44. doi: 10.1128/iai.55.11.2636-2644.1987.
8
Isolation and characterization of murine monoclonal antibodies specific for gram-negative bacterial lipopolysaccharide: association of cross-genus reactivity with lipid A specificity.针对革兰氏阴性菌脂多糖的小鼠单克隆抗体的分离与鉴定：跨属反应性与脂质A特异性的关联
Infect Immun. 1987 Apr;55(4):899-908. doi: 10.1128/iai.55.4.899-908.1987.
9
Characterization of murine monoclonal antibodies to Escherichia coli J5.抗大肠杆菌J5鼠单克隆抗体的特性分析
Infect Immun. 1986 Apr;52(1):56-62. doi: 10.1128/iai.52.1.56-62.1986.
10
Endotoxin neutralization with rabbit antisera to Escherichia coli J5 and other gram-negative bacteria.用兔抗大肠杆菌J5及其他革兰氏阴性菌抗血清进行内毒素中和
Infect Immun. 1987 Jul;55(7):1668-73. doi: 10.1128/iai.55.7.1668-1673.1987.

本文引用的文献

1
SEPARATION, CHARACTERIZATION, AND BIOLOGICAL SIGNIFICANCE OF A COMMON ANTIGEN IN ENTEROBACTERIACEAE.肠杆菌科中一种共同抗原的分离、鉴定及生物学意义
J Exp Med. 1963 Oct 1;118(4):565-86. doi: 10.1084/jem.118.4.565.
2
Immunochemical studies of human serum Rh agglutinins.人血清Rh凝集素的免疫化学研究。
J Immunol. 1960 Jul;85:37-45.
3
Increased resistance to infection and accompanying alteration in properidin levels following administration of bacterial lipopolysaccharides.给予细菌脂多糖后抗感染能力增强及备解素水平随之改变。
J Exp Med. 1956 Sep 1;104(3):383-409. doi: 10.1084/jem.104.3.383.
4
Rapidly induced changes in the level of non-specific immunity in laboratory animals.实验动物非特异性免疫水平的快速诱导变化。
Br J Exp Pathol. 1956 Jun;37(3):223-34.
5
Stimulation of natural immunity to Escherichia coli infection: observations on mice.对大肠杆菌感染天然免疫的刺激：对小鼠的观察
Lancet. 1955 Jan 29;268(6857):232-4. doi: 10.1016/s0140-6736(55)90163-x.
6
[A new group of Salmonella R mutants. Serologic and biochemical analysis of the heptoses from the lipopolysaccharides from Salmonella minnesota and Salmonella ruiru mutants].[一组新的沙门氏菌R突变体。明尼苏达沙门氏菌和鲁伊鲁沙门氏菌突变体脂多糖中庚糖的血清学和生化分析]
Eur J Biochem. 1967 Apr;1(2):216-32. doi: 10.1111/j.1432-1033.1967.tb00066.x.
7
A new method for the extraction of R lipopolysaccharides.一种提取R脂多糖的新方法。
Eur J Biochem. 1969 Jun;9(2):245-9. doi: 10.1111/j.1432-1033.1969.tb00601.x.
8
Endotoxin and bacteremia due to gram-negative organisms.革兰氏阴性菌引起的内毒素血症和菌血症。
N Engl J Med. 1970 Dec 10;283(24):1342-3. doi: 10.1056/NEJM197012102832412.
9
Immunochemistry of O and R antigens of Salmonella and related Enterobacteriaceae.沙门氏菌及相关肠杆菌科细菌O抗原和R抗原的免疫化学
Bacteriol Rev. 1966 Mar;30(1):192-255. doi: 10.1128/br.30.1.192-255.1966.
10
Type-specific and cross-reactive antibodies in gram-negative bacteremia.革兰氏阴性菌血症中的型特异性抗体和交叉反应性抗体。
N Engl J Med. 1972 Aug 10;287(6):261-7. doi: 10.1056/NEJM197208102870601.

用来自明尼苏达沙门氏菌R595的脂多糖A抗血清预防革兰氏阴性菌感染。

Protection against gram-negative infections with antiserum to lipid A from Salmonella minnesota R595.

作者信息

Mullan N A, Newsome P M, Cunnington P G, Palmer G H, Wilson M E

出版信息

Infect Immun. 1974 Dec;10(6):1195-201. doi: 10.1128/iai.10.6.1195-1201.1974.

DOI:10.1128/iai.10.6.1195-1201.1974
PMID:4611919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC423086/
Abstract

The ability of antisera to lipid A, induced in rabbits by immunization with lipid A complexed to various carriers, to protect mice against gram-negative infection and to inhibit the fluid loss caused by an enteropathogenic strain of Escherichia coli in the piglet ligated gut was investigated. No significant protection was obtained in either case, although passive hemolysis and quantitative precipitation tests showed the presence of antilipid A antibodies in the sera. Fluorescent antibody studies suggest that the lipid A is in a cryptic position on the surface of smooth strains of gram-negative bacteria.

摘要

研究了用与各种载体复合的脂多糖免疫家兔诱导产生的抗脂多糖血清保护小鼠抵抗革兰氏阴性菌感染以及抑制致病性大肠杆菌菌株在仔猪结扎肠段引起的液体流失的能力。尽管被动溶血和定量沉淀试验表明血清中存在抗脂多糖抗体，但在这两种情况下均未获得显著的保护作用。荧光抗体研究表明，脂多糖在革兰氏阴性菌光滑菌株表面处于隐蔽位置。