Voller A, Bruce-Chwatt L J
Bull World Health Organ. 1968;39(6):883-97.
A parasitological and serological malaria survey of 2 large and 2 small areas of Nigeria was carried out in connexion with the activities of the WHO Treponematoses Epidemiological Team.The results, based on data obtained from 1082 subjects, showed that all the areas were holoendemic with the usual pattern of malariometric indices, and that the differences between the parasite rates of the two large areas were due to the different timing of the survey in relation to the seasonal wave of transmission.The fluorescent antibody test was positive (>/=1:20) in 92% of the 914 sera collected from these 2 areas.The serological profile of the population in the 2 areas was similar, but the immunofluorescence titres were higher in all age-groups in the area south of the Benue river, indicating the antibody response to the previous endemic wave rather than the actual amount of transmission taking place at the time of the survey.This study confirms the value of the immunofluorescent technique for large-scale malaria surveys, but indicates the need for caution in interpreting the results and stresses the importance of good knowledge of the local epidemiology of malaria before embarking on application of serological methods.
结合世界卫生组织密螺旋体病流行病学团队的活动，对尼日利亚的2个大区域和2个小区域进行了疟疾寄生虫学和血清学调查。基于从1082名受试者获得的数据的结果显示，所有区域均为高度流行区，具有常见的疟疾测量指标模式，并且两个大区域的寄生虫率差异是由于调查时间与季节性传播波的关系不同所致。在从这2个区域采集的914份血清中，92%的血清荧光抗体试验呈阳性（>/=1:20）。这2个区域人群的血清学特征相似，但贝努埃河以南地区所有年龄组的免疫荧光滴度较高，这表明是对先前流行波的抗体反应，而非调查时实际发生的传播量。本研究证实了免疫荧光技术在大规模疟疾调查中的价值，但表明在解释结果时需要谨慎，并强调在应用血清学方法之前，充分了解当地疟疾流行病学的重要性。
