Iudaev N A, Asribekova M K, Karpova S K, Kaganovich B E
Probl Endokrinol (Mosk). 1979 May-Jun;25(3):37-42.
Hormonal control of progesterone and estradiol receptors was studied in the cytozol of short-lived culture of human endometrium in normal and undeveloping pregnancy. Endometrium was cultivated in the presence of estradiol or progesterone for 16 hours. In cultivation of normal endometrium with estradiol the content of estradiol receptors increased 4-fold in comparison with unstimulated tissue, and of progesteron receptors--3-fold. In cultivation of normal endometrium with progesterone the content of estradiol receptors rose 4--5-fold, and of progesterone receptors--3-fold. In cultivation of pathological endometrium with estradiol or progesterone the number of estradiol receptors was only doubled, and of progesterone receptors--increased only 1 1/2 times, this pointing to a diminished sensitivity of pathological endometrium to the regulating action of sex hormones.
在正常及未发育妊娠状态下，对人子宫内膜短期培养的细胞溶质中孕酮和雌二醇受体的激素调控进行了研究。将子宫内膜在雌二醇或孕酮存在的情况下培养16小时。在用雌二醇培养正常子宫内膜时，与未受刺激的组织相比，雌二醇受体含量增加了4倍，孕酮受体含量增加了3倍。在用孕酮培养正常子宫内膜时，雌二醇受体含量上升了4至5倍，孕酮受体含量增加了3倍。在用雌二醇或孕酮培养病理性子宫内膜时，雌二醇受体数量仅增加了一倍，孕酮受体数量仅增加了1.5倍，这表明病理性子宫内膜对性激素调节作用的敏感性降低。
