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来自卡介苗的具有血清学活性的糖脂家族。I. 提取、纯化及免疫学研究。

Serologically active glycolipid families from Mycobacterium bovis BCG. I. Extraction, purification and immunologic studies.

作者信息

Reggiardo Z, Middlebrook G

出版信息

Am J Epidemiol. 1974 Dec;100(6):469-76. doi: 10.1093/oxfordjournals.aje.a112059.

DOI:10.1093/oxfordjournals.aje.a112059
PMID:4614667
Abstract

Glycolipids were extracted from mycobacteria with methanol and chloroform and purified by silicic acid chromatography. These glycolipids were studied for their serologic activity by direct and indirect (Coomb's) passive hemagglutination, and by inhibition methods. Three families of serologically active glycolipids called A, B and C, plus cardiolipin, were isolated. The B and C families of glycolipids were reactive with sera from BCG immunized rabbits and also with sera from patients with tuberculosis and leprosy; the A family was reactive only with the human sera. None of the serologically active glycolipids was able to protect rabbits against tuberculosis.

摘要

用甲醇和氯仿从分枝杆菌中提取糖脂，并通过硅酸色谱法进行纯化。通过直接和间接（库姆斯氏）被动血凝反应以及抑制法研究了这些糖脂的血清学活性。分离出了三个具有血清学活性的糖脂家族，分别称为A、B和C，外加心磷脂。糖脂的B家族和C家族与卡介苗免疫兔的血清以及结核病和麻风病患者的血清都有反应；A家族仅与人血清有反应。没有一种具有血清学活性的糖脂能够保护兔子免受结核病感染。

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1
Serologically active glycolipid families from Mycobacterium bovis BCG. I. Extraction, purification and immunologic studies.来自卡介苗的具有血清学活性的糖脂家族。I. 提取、纯化及免疫学研究。
Am J Epidemiol. 1974 Dec;100(6):469-76. doi: 10.1093/oxfordjournals.aje.a112059.
2
Serologically active glycolipid families from Mycobacterium bovis BCG. II. Serologic studies on human sera.来自卡介苗的具有血清学活性的糖脂家族。II. 对人血清的血清学研究。
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Serological response in leprosy and tuberculosis patients to the 18-kDa antigen of Mycobacterium leprae and antigen 85B of Mycobacterium bovis BCG.麻风病和结核病患者对麻风分枝杆菌18-kDa抗原及卡介苗（牛分枝杆菌卡介苗）85B抗原的血清学反应。
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引用本文的文献

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Glycolipids of Mycobacterium tuberculosis strain H37Rv are potential serological markers for diagnosis of active tuberculosis.结核分枝杆菌H37Rv菌株的糖脂是诊断活动性结核病的潜在血清学标志物。
Clin Diagn Lab Immunol. 2005 Mar;12(3):465-73. doi: 10.1128/CDLI.12.3.465-473.2005.
2
Comparison of enzyme-linked immunosorbent assay and hemagglutination test using mycobacterial glycolipids.使用分枝杆菌糖脂的酶联免疫吸附测定和血凝试验的比较。
J Clin Microbiol. 1981 May;13(5):1007-9. doi: 10.1128/jcm.13.5.1007-1009.1981.
3
Serological activity of a characteristic phenolic glycolipid from Mycobacterium leprae in sera from patients with leprosy and tuberculosis.
麻风分枝杆菌特征性酚糖脂在麻风病和结核病患者血清中的血清学活性。
Clin Exp Immunol. 1983 May;52(2):271-9.
4
Protective immunity to experimental tuberculosis by mannophosphoinositides of mycobacteria.分枝杆菌甘露糖磷酸肌醇对实验性结核病的保护性免疫
Med Microbiol Immunol. 1988;177(5):265-84. doi: 10.1007/BF00189412.
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The 45 kilodalton molecule of Mycobacterium tuberculosis identified by immunoblotting and monoclonal antibodies as antigenic in patients with tuberculosis.通过免疫印迹法和单克隆抗体鉴定出的结核分枝杆菌45千道尔顿分子，在结核病患者中具有抗原性。
Br J Exp Pathol. 1989 Apr;70(2):215-25.
6
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Infect Immun. 1976 Dec;14(6):1369-74. doi: 10.1128/iai.14.6.1369-1374.1976.
7
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Infect Immun. 1978 Sep;21(3):914-7. doi: 10.1128/iai.21.3.914-917.1978.