分枝杆菌糖脂A1的抗肿瘤活性。
Antitumor activity of mycobacterial glycolipid A1.
作者信息
Reggiardo Z
出版信息
Infect Immun. 1978 Sep;21(3):914-7. doi: 10.1128/iai.21.3.914-917.1978.
Abstract
Glycolipid A1 isolated from Mycobacterium bovis BCG, when dissolved in olive oil and injected together with Line 10 transplantable hepatoma cells, is able to elicit a host response which results in the abrogation or retardation of tumor growth in syngeneic guinea pigs. Glycolipid A1 does not have adjuvant activity for delayed type hypersensitivity, and antibodies to A1 have not been detected in the sera of guinea pigs during or after the tumor abrogation induced by A1 injection Glycolipid A1 does not share antigenic determinants with Line 10 cell lipid fractions. The possible role of the granuloma response elicited by A1 in controlling tumor growth is discussed.
摘要
从卡介苗中分离出的糖脂A1，溶解于橄榄油并与10号线可移植肝癌细胞一同注射时，能够引发宿主反应，导致同基因豚鼠体内肿瘤生长被消除或延缓。糖脂A1对迟发型超敏反应没有佐剂活性，在注射A1诱导肿瘤消除期间或之后，豚鼠血清中未检测到A1抗体。糖脂A1与10号线细胞脂质组分不共享抗原决定簇。文中讨论了A1引发的肉芽肿反应在控制肿瘤生长中可能发挥的作用。
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