恶性黑色素瘤患者中携带过量IgD的淋巴细胞。
Excess IgD bearing lymphocytes in patients with malignant melanoma.
作者信息
Malka S, Oon C J, Hobbs J R
出版信息
Br J Cancer. 1974 Nov;30(5):379-81. doi: 10.1038/bjc.1974.211.
Abstract
B lymphocytes from the peripheral blood of 15 melanoma patients and 14 normal adults were studied using immunofluorescence to IgA, IgG, IgD and IgM surface markers. The total number of peripheral blood B lymphocytes was increased in the melanoma patients (1048/mm(3)) compared with normal controls (504) (P<0·01).The expression of excess IgD bearing lymphocytes in these melanoma patients may reflect a derepression of oncofoetal type.
摘要
运用免疫荧光法检测15例黑色素瘤患者及14例正常成年人外周血中的B淋巴细胞表面免疫球蛋白A（IgA）、免疫球蛋白G（IgG）、免疫球蛋白D（IgD）及免疫球蛋白M（IgM）标志物。黑色素瘤患者外周血B淋巴细胞总数（1048/mm³）高于正常对照组（504/mm³）（P<0.01）。这些黑色素瘤患者中携带过量IgD的淋巴细胞的表达可能反映了癌胚型的去抑制状态。
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