Traub W H, Raymond E A
Appl Microbiol. 1972 Jan;23(1):4-7. doi: 10.1128/am.23.1.4-7.1972.
The in vitro activity of tobramycin was quantitatively compared with that of gentamicin sulfate against 195 bacterial isolates from clinical material. Tobramycin was found to be twice as active as gentamicin against isolates of Pseudomonas aeruginosa. Conversely, gentamicin proved fourfold more active than tobramycin against isolates of Serratia marcescens. Both drugs were of comparable activity against isolates of Staphylococcus aureus and the majority of the enterobacterial isolates other than S. marcescens. On the basis of the obtained data, the following criteria are proposed for the interpretation of diffusion susceptibility tests with 10-mug discs of gentamicin and tobramycin. Enterobacteriaceae and isolates of S. aureus are designated as susceptible to gentamicin and tobramycin if the zones of inhibition measure 15 mm or more in diameter; zones of 14 mm or less are indicative of resistance. Pseudomonadaceae are interpreted as sensitive to tobramycin and gentamicin if the inhibition zones measure at least 15 and 12 mm in diameter, respectively.
将妥布霉素的体外活性与硫酸庆大霉素针对195株临床材料分离菌的活性进行了定量比较。结果发现，妥布霉素对铜绿假单胞菌分离株的活性是庆大霉素的两倍。相反，庆大霉素对粘质沙雷氏菌分离株的活性比妥布霉素高四倍。两种药物对金黄色葡萄球菌分离株以及除粘质沙雷氏菌外的大多数肠杆菌科分离株的活性相当。根据所得数据，提出以下标准用于解释用10微克庆大霉素和妥布霉素纸片进行的扩散药敏试验结果。如果抑菌圈直径为15毫米或更大，则肠杆菌科细菌和金黄色葡萄球菌分离株对庆大霉素和妥布霉素敏感；直径为14毫米或更小的抑菌圈表明耐药。如果假单胞菌科细菌的抑菌圈直径分别至少为15毫米和12毫米，则对妥布霉素和庆大霉素敏感。
