与医院获得性尿路感染暴发相关的一株罕见雷氏变形杆菌的特性分析。
Characterization of an unusual strain of proteus rettgeri associated with an outbreak of nosocomial urinary-tract infection.
作者信息
Traub W H, Craddock M E, Raymond E A, Fox M, McCall C E
出版信息
Appl Microbiol. 1971 Sep;22(3):278-83. doi: 10.1128/am.22.3.278-283.1971.
Abstract
An outbreak of nosocomial urinary-tract infection was caused by a strain of Proteus rettgeri that fermented lactose overnight and was resistant to all antimicrobial drugs tested. The nonmotile isolates shared an O (somatic) antigen that differed from those of wild-type P. rettgeri. The organisms proved markedly serum-sensitive. In rats, the isolates elicited an acute interstitial nephritis with associated transient bacteriuria. Attempts to transfer the lac(+) trait and drug-resistance markers to recipient strains of Escherichia coli K-12 failed; exposure of the isolates to acridine orange yielded small numbers of non-lactose-fermenting variants which, however, were still as drug-resistant as before. Epidemiological studies failed to uncover the source of this unique strain and appeared to indicate exogenous spread of infection.
摘要
一次医院内尿路感染暴发是由一株雷特格变形杆菌引起的，该菌株能在一夜之间发酵乳糖，并且对所有测试的抗菌药物均耐药。这些无动力分离株共有一种O（菌体）抗原，与野生型雷特格变形杆菌的抗原不同。这些细菌对血清极为敏感。在大鼠中，这些分离株引发了急性间质性肾炎并伴有短暂菌尿。将乳糖发酵阳性（lac(+)）性状和耐药标记转移至大肠杆菌K-12受体菌株的尝试失败了；将这些分离株暴露于吖啶橙后产生了少量非乳糖发酵变体，然而，这些变体仍然像之前一样耐药。流行病学研究未能发现这种独特菌株的来源，似乎表明感染是外源性传播。
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