Cradock-Watson J E, Bourne M S, Vandervelde E M
J Hyg (Lond). 1972 Sep;70(3):473-85. doi: 10.1017/s0022172400063063.
The indirect immunofluorescent technique has been used to study the specific immunoglobulin responses in twelve adult cases of acute uncomplicated rubella. IgG, IgA and IgM antibodies increased virtually simultaneously. IgG antibody persisted throughout the period of study but showed a slight tendency to fall in titre after 7 months. IgM antibody was detected in nine cases. In these patients it was present in high titre 5-15 days after the rash but was not detected after 20 days. IgA antibody was detected in all cases. It was present in high titre 5-20 days after the rash but was no longer detectable after 29 days except in one patient who had a very low titre at 78 days. The presence of specific IgA and IgM indicates recent rubella in uncomplicated cases, and if the immunofluorescent method is used both types of antibody should be sought.
间接免疫荧光技术已用于研究12例成人急性非复杂性风疹病例的特异性免疫球蛋白反应。IgG、IgA和IgM抗体几乎同时升高。IgG抗体在整个研究期间持续存在，但在7个月后滴度略有下降趋势。9例检测到IgM抗体。在这些患者中，皮疹出现后5 - 15天IgM抗体呈高滴度，但20天后未检测到。所有病例均检测到IgA抗体。皮疹出现后5 - 20天IgA抗体呈高滴度，但29天后除1例在78天时有非常低的滴度外均不再可检测到。特异性IgA和IgM的存在表明非复杂性病例近期感染了风疹，并且如果使用免疫荧光法，应同时寻找这两种抗体。
