Cradock-Watson J E, Ridehalgh M K, Bourne M S, Vandervelde E M
J Hyg (Lond). 1973 Sep;71(3):603-17. doi: 10.1017/s002217240004660x.
The indirect immunofluorescent technique has been used to study the specific immunoglobulin responses in nasal secretions from ten adults with acute rubella. Titres of IgA antibody in nasal washings usually exceeded those of IgG, but both types of antibody were detected in all patients. They appeared a few days after the rash, reached maximum titres during the second week and then declined. IgA antibody was no longer detectable after 47 days and was not detected at all in nasal washings from adults who had experienced rubella in the past. Low titres of IgG antibody persisted in some patients for longer than IgA and traces of IgG were found in nasal washings from a minority of adults with a past history of rubella. Nasal antibodies in acute rubella are therefore transient and unlikely to take part in resistance to reinfection.In sucrose-density gradients nasal IgA antibody sedimented more rapidly than IgG and there was little overlap between these two types of antibody. IgA antibody in serum was more heterogeneous; it was found in nearly all the fractions which contained IgG antibody and in many of those which contained IgM.
间接免疫荧光技术已被用于研究10名患急性风疹的成年人鼻分泌物中的特异性免疫球蛋白反应。鼻洗液中IgA抗体的滴度通常超过IgG，但所有患者均检测到这两种抗体。它们在皮疹出现几天后出现，在第二周达到最高滴度，然后下降。47天后IgA抗体不再能被检测到，在过去患过风疹的成年人的鼻洗液中根本检测不到。一些患者中低滴度的IgG抗体比IgA持续时间更长，少数有风疹病史的成年人的鼻洗液中发现有微量IgG。因此，急性风疹中的鼻抗体是短暂的，不太可能参与对再感染的抵抗。在蔗糖密度梯度中，鼻IgA抗体比IgG沉淀得更快，这两种抗体之间几乎没有重叠。血清中的IgA抗体更具异质性；在几乎所有含有IgG抗体的组分以及许多含有IgM的组分中都发现了它。
