Tret'iakov A V, Filov V A, Riazanov E M, Tarkov A S
Vopr Onkol. 1979;25(6):100-3.
It was found that under the influence of hydrazine sulfate, which in the dosage of 60 mg/kg would induce a 50% suppression of Walker carcinosarcoma in rats, there is the decreased activity of mitochondrial monoamine oxidase and a sharp reduction in the activity of some microsomal phosphatases. Vitamin B6 injection some hours before injecting hydrazine sulfate lessens the rate of suppression of the tumor growth up to 50%. The results obtained indicate that the antitumor effect of hydrazine sulfate may be related to the suppressed monoamine oxidate activity and vitamin B6 deficiency.
据发现，在硫酸肼的影响下（其剂量为60毫克/千克时可使大鼠的沃克癌肉瘤抑制50%），线粒体单胺氧化酶的活性降低，一些微粒体磷酸酶的活性急剧下降。在注射硫酸肼前数小时注射维生素B6，可使肿瘤生长的抑制率降低至50%。所得结果表明，硫酸肼的抗肿瘤作用可能与单胺氧化酶活性受到抑制以及维生素B6缺乏有关。
