• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

氯贝丁酯对硫酸肼及细胞毒性药物在沃克256癌肉瘤体内抑制肿瘤作用的增强效应

Potentiation by clofibrate of in-vivo tumor inhibition by hydrazine sulfate and cytotoxic agents, in Walker 256 carcinosarcoma.

作者信息

Gold J

出版信息

Cancer Biochem Biophys. 1978;3(1):41-5.

PMID:552898
Abstract

Clofibrate as a sole agent was found to have statistically perceptible antitumor effects against the in vivo growth of Walker 256 intramuscular carcinosarcoma in rats. Clofibrate was also found to potentiate the antitumor effect of hydrazine sulfate, cytotoxic drugs and the combination of hydrazine sulfate + cytotoxic drug. The results suggest that substances which might directly or indirectly interfere with host lipogenesis and/or lipolysis, may also have adjunctal antitumor potential.

摘要

发现安妥明作为单一药剂，对大鼠体内Walker 256肌内癌肉瘤的生长具有统计学上可察觉的抗肿瘤作用。还发现安妥明可增强硫酸肼、细胞毒性药物以及硫酸肼+细胞毒性药物组合的抗肿瘤作用。结果表明，可能直接或间接干扰宿主脂肪生成和/或脂肪分解的物质，也可能具有辅助抗肿瘤潜力。

相似文献

1
Potentiation by clofibrate of in-vivo tumor inhibition by hydrazine sulfate and cytotoxic agents, in Walker 256 carcinosarcoma.氯贝丁酯对硫酸肼及细胞毒性药物在沃克256癌肉瘤体内抑制肿瘤作用的增强效应
Cancer Biochem Biophys. 1978;3(1):41-5.
2
Enhancement by hydrazine sulfate of antitumor effectiveness of cytoxan, mitomycin C, methotrexate and bleomycin, in walker 256 carcinosarcoma in rats.硫酸肼对环磷酰胺、丝裂霉素C、甲氨蝶呤和博来霉素在大鼠沃克256癌肉瘤中抗肿瘤效果的增强作用。
Oncology. 1975;31(1):44-53. doi: 10.1159/000225004.
3
[Experimental data to substantiate the antitumor action of hydrazine sulfate].[证实硫酸肼抗肿瘤作用的实验数据]
Vopr Onkol. 1979;25(6):100-3.
4
[Selective action of hydrazine sulfate in combination with thiophosphamide on tumor cell mitochondria].硫酸肼与硫代磷酰胺联合对肿瘤细胞线粒体的选择性作用
Vopr Onkol. 1982;28(3):86-8.
5
[Experimental and clinical data on the antitumor action of hydrazine sulfate].
Vopr Onkol. 1975;21(1):45-52.
6
[Experimental data on the toxic action of hydrazine sulfate on the body and on a tumor].[硫酸肼对机体及肿瘤毒性作用的实验数据]
Farmakol Toksikol. 1978 Mar-Apr;41(2):203-5.
7
Toxicity of intrathecally administered cytotoxic drugs and their antitumor activity against an intrathecal Walker 256 carcinosarcoma model for meningeal carcinomatosis in the rat.鞘内注射细胞毒性药物的毒性及其对大鼠脑膜癌病鞘内Walker 256癌肉瘤模型的抗肿瘤活性。
Cancer Res. 1989 Feb 15;49(4):977-82.
8
Antitumor effect of N alpha-benzyloxycarbonyl-N,N-bis-(2-halogenethyl)-hydrazide derivatives of amino acids.氨基酸的Nα-苄氧羰基-N,N-双-(2-卤代乙基)-酰肼衍生物的抗肿瘤作用
Neoplasma. 1980;27(2):137-42.
9
Enhancement of antitumor activity of 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine and Baker's antifol (triazinate) with carboxypeptidase G1.羧肽酶G1增强2,4-二氨基-5-(3',4'-二氯苯基)-6-甲基嘧啶和贝克抗叶酸剂（三嗪酸盐）的抗肿瘤活性。
Cancer Res. 1979 Sep;39(9):3441-5.
10
In vivo synergy of vitamin K3 and methotrexate in tumor-bearing animals.
Cancer Treat Rep. 1986 Dec;70(12):1433-5.

引用本文的文献

1
Unconventional therapies for cancer: 4. Hydrazine sulfate. Task Force on Alternative Therapies of the Canadian Breast Cancer Research Initiative.癌症的非常规疗法：4. 硫酸肼。加拿大乳腺癌研究倡议替代疗法特别工作组。
CMAJ. 1998 May 19;158(10):1327-30.
2
Loss of acetoacetate coenzyme A transferase activity in tumours of peripheral tissues.外周组织肿瘤中乙酰乙酸辅酶A转移酶活性丧失。
Br J Cancer. 1983 Feb;47(2):293-7. doi: 10.1038/bjc.1983.38.