Gold J
Oncology. 1975;31(1):44-53. doi: 10.1159/000225004.
Use of hydrazine sulfate potentiates the antitumor action of Cytoxan (cyclophosphamide), Mitomycin C, methotrexate and bleomycin against Walker 256 intramuscular carcinosarcoma in in vivo short-term studies in rats. Experimental data suggest this potentiation by hydrazine sulfate to result from a mechanism of action other than direct cytotoxicity, and further, that combination chemotherapy with hydrazine sulfate and a cytotoxic agent may be useful in the treatment of human cancer.
在大鼠体内短期研究中，硫酸肼的使用增强了环磷酰胺、丝裂霉素C、甲氨蝶呤和博来霉素对Walker 256肌内癌肉瘤的抗肿瘤作用。实验数据表明，硫酸肼的这种增强作用源于一种不同于直接细胞毒性的作用机制，此外，硫酸肼与细胞毒性药物的联合化疗可能对人类癌症的治疗有用。
