Filov V A, Stukov A N, Blank M A, Neĭshtadt E L
Farmakol Toksikol. 1978 Mar-Apr;41(2):203-5.
Toxic action of hydrozine sulfate in rats and mice along with its influence on the mitotic activity of Walker carcino-sarcoma cells were studied. Single injections of the agent in high doses resulted in destruction of the animals during the first 2 days with no "delayed death" observed. Multiple injections caused a considerable loss of body weight. When given in toxic doses the agent did not influence hemopoiesis, but did affect sensitivity, drastically increasing the toxic action of ethanol or barbiturates. Administration of hydrazine sulfate in therapeutic doses decreased markedly the mitotic activity and increased the appearance of atypical mitotic cells.
研究了硫酸肼对大鼠和小鼠的毒性作用及其对Walker癌肉瘤细胞有丝分裂活性的影响。高剂量单次注射该药物会导致动物在头两天内死亡，未观察到“延迟死亡”。多次注射会导致体重显著减轻。给予毒性剂量时，该药物不影响造血，但会影响敏感性，显著增加乙醇或巴比妥类药物的毒性作用。以治疗剂量给予硫酸肼会显著降低有丝分裂活性，并增加非典型有丝分裂细胞的出现。
