Rømer F K, Christiansen S E, Kragballe K, Herlin T, Madsen M
Clin Exp Immunol. 1984 Nov;58(2):357-63.
In 14 patients with pulmonary sarcoidosis and 14 matched controls we studied peripheral blood lymphocyte and monocyte counts, distribution of T and B lymphocytes, the functional helper:suppressor T cell balance, the antibody-dependent cell-mediated cytotoxicity of monocytes (monocyte ADCC), and the capacity of peripheral monocytes to generate angiotensin converting enzyme (ACE) in culture. Apart from lymphopenia in sarcoidosis patients we found a normal lymphocyte subset distribution and no evidence of increased suppressor T cell activity, using a PWM driven proliferative assay. The patients exhibited a normal monocyte count, but the proportion of monocytes was increased in sarcoidosis. Patients with active sarcoidosis had a significantly increased monocyte ADCC which was positively correlated with raised serum ACE. Peripheral monocytes had a measurable, but low ACE activity, which was modestly higher in active sarcoidosis than in controls. We could not reproduce earlier reported results on a glucocorticoid induced ACE synthesis from cultured human monocytes.
我们对14例肺结节病患者和14例匹配的对照者进行了研究，检测外周血淋巴细胞和单核细胞计数、T和B淋巴细胞分布、功能性辅助性T细胞与抑制性T细胞平衡、单核细胞的抗体依赖性细胞介导的细胞毒性（单核细胞ADCC）以及外周单核细胞在培养中产生血管紧张素转换酶（ACE）的能力。除结节病患者存在淋巴细胞减少外，我们通过PWM驱动的增殖试验发现淋巴细胞亚群分布正常，且无抑制性T细胞活性增加的证据。患者单核细胞计数正常，但结节病患者中单核细胞比例增加。活动性结节病患者的单核细胞ADCC显著增加，且与血清ACE升高呈正相关。外周单核细胞具有可测量但较低的ACE活性，活动性结节病患者的该活性略高于对照组。我们无法重现先前报道的关于糖皮质激素诱导培养的人单核细胞合成ACE的结果。
