倍他司汀对清醒犬胃酸分泌及黏膜血流的影响。
The effect of betahistine on gastric acid secretion and mucosal blood flow in conscious dogs.
作者信息
Curwain B P, Holton P, Spencer J
出版信息
Br J Pharmacol. 1972 Oct;46(2):351-4. doi: 10.1111/j.1476-5381.1972.tb06881.x.
Abstract
In 3 conscious dogs, betahistine (2-(2'-methyl aminoethyl pyridine)) (80 or 160mug kg(-1) min(-1)) increased acid secretion from Heidenhain pouches to 8.8% and 17.6% respectively of the maximal response to histamine. Betahistine also increased mucosal blood flow (radioactive aniline clearance). The ratio of mucosal blood flow to secretion was greater for betahistine than for histamine but the difference between betahistine and histamine was significant in only one of the dogs.
摘要
在3只清醒犬中，倍他司汀（2-(2'-甲氨基乙基)吡啶）（80或160μg kg⁻¹ min⁻¹）使海登海因小胃的胃酸分泌分别增加至组胺最大反应的8.8%和17.6%。倍他司汀还增加了黏膜血流量（放射性苯胺清除率）。倍他司汀的黏膜血流量与分泌量之比高于组胺，但仅在其中1只犬中倍他司汀与组胺之间的差异具有统计学意义。
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