选择性IgA缺乏症患者体内针对人胶原蛋白的抗体。
Antibodies to human collagen in subjects with selective IgA deficiency.
作者信息
Wells J V, Michaeli D, Fudenberg H H
出版信息
Clin Exp Immunol. 1973 Feb;13(2):203-8.
Abstract
Antibodies to native human collagen were detected by passive haemagglutination in the serum of sixteen of thirty-six subjects with selective TgA deficiency (44·4%), compared to 2·5% of control subjects. The sixteen subjects with anti-collagen antibodies inculded four asymptomatic subjects, five with recurrent infections, four with ataxia telangiectasia, and one each with lymphoma, asthma, and rheumatoid arthritis. There was no statistically significant correlation in individual subjects between the presence of anti-collagen antibodies and antibodies to human IgG, IgA, IgM and ruminant proteins.
摘要
在36例选择性IgA缺乏症患者中，有16例（44.4%）血清通过被动血凝反应检测到抗天然人胶原蛋白抗体，而对照组中这一比例为2.5%。这16例有抗胶原蛋白抗体的患者包括4例无症状者、5例反复感染者、4例共济失调毛细血管扩张症患者，以及各1例患淋巴瘤、哮喘和类风湿关节炎的患者。个体患者中，抗胶原蛋白抗体的存在与抗人IgG、IgA、IgM及反刍动物蛋白抗体之间无统计学显著相关性。
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Antibodies to human collagen in subjects with selective IgA deficiency.选择性IgA缺乏症患者体内针对人胶原蛋白的抗体。
Clin Exp Immunol. 1973 Feb;13(2):203-8.
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Localization of antigenic determinants in the polypeptide chains of collagen.抗原决定簇在胶原蛋白多肽链中的定位。
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