正常个体及甲型血友病患者淋巴细胞培养物中的组织因子活性。
Tissue factor activity in lymphocyte cultures from normal individuals and patients with hemophilia A.
作者信息
Rickles F R, Hardin J A, Pitlick F A, Hoyer L W, Conrad M E
出版信息
J Clin Invest. 1973 Jun;52(6):1427-34. doi: 10.1172/JCI107316.
Abstract
The procoagulant material of lymphocytes has been characterized as tissue factor. Lymphocytes stimulated with phytohemagglutinin or the purified protein derivative of the tubercle bacillus developed procoagulant activity with incubation in tissue culture. While this material corrected the prolonged clotting time of factor VIII (AHF) deficient plasma, we have shown, utilizing a sensitive radioimmunoassay, that no AHF antigen was present in the cell cultures. Further, we have demonstrated this material to be tissue factor by coagulation techniques and immunological cross-reactivity. The published data regarding factor VIII synthesis is reviewed in light of these observations and comments are made regarding the role of the lymphocyte procoagulant.
摘要
淋巴细胞的促凝物质已被鉴定为组织因子。用植物血凝素或结核杆菌纯化蛋白衍生物刺激的淋巴细胞，在组织培养中孵育后会产生促凝活性。虽然这种物质能纠正因子VIII（抗血友病因子）缺乏血浆延长的凝血时间，但我们利用灵敏的放射免疫测定法表明，细胞培养物中不存在抗血友病因子抗原。此外，我们通过凝血技术和免疫交叉反应证明这种物质就是组织因子。根据这些观察结果对已发表的关于因子VIII合成的数据进行了综述，并对淋巴细胞促凝剂的作用发表了评论。
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