Modification of the colorimetric assay for chloramphenicol in the presence of bilirubin.
作者信息
Mason E O, Kaplan S L, Baker C J, Ritter D A
出版信息
Antimicrob Agents Chemother. 1979 Apr;15(4):544-6. doi: 10.1128/AAC.15.4.544.
Abstract
We recently found that bilirubin interferes with the colorimetric chloramphenicol assay of Kakemi et al. (K. T. Kakemi, T. Arita, and S. Ohashi, Yakugaku Zasshi 82:342-345, 1962). Levels of serum bilirubin alone (4 to 6 mg/dl) resulted in apparent concentrations of chloramphenicol which appear to be in the therapeutic range. Concentrations of serum bilirubin greater than 8 mg/dl resulted in levels of apparent chloramphenicol associated with toxicity (>50 mug/ml). Small amounts of activated charcoal added to the isoamyl acetate extraction step of the assay eliminated this interference by bilirubin.
摘要
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本文引用的文献
1
[Absorption and excretion of drugs. V. Determination of chloramphenicol in urine and its metabolic rate].
Yakugaku Zasshi. 1962 Mar;82:345-8.
2
CHLORAMPHENICOL IN BLOOD: SIMPLE CHEMICAL ESTIMATIONS IN PATIENTS RECEIVING MULTIPLE ANTIBIOTICS.
Science. 1964 Apr 17;144(3616):296-7. doi: 10.1126/science.144.3616.296.
3
Chloramphenicol in the newborn infant. A physiologic explanation of its toxicity when given in excessive doses.
N Engl J Med. 1960 Apr 21;262:787-94. doi: 10.1056/NEJM196004212621601.
4
Determination of serum chloramphenicol utilizing gas--liquid chromatography and electron capture spectrometry.
Anal Chem. 1966 Apr;38(4):582-5. doi: 10.1021/ac60236a014.
5
Rapid microassay of gentamicin, kanamycin, neomycin, streptomycin, and vancomycin in serum or plasma.
J Lab Clin Med. 1971 Sep;78(3):457-63.
6
Determination of unbound bilirubin in the serum of newborns.
Clin Chem. 1974 Jul;20(7):783.
7
Chloramphenicol: an enzymological microassay.
Antimicrob Agents Chemother. 1976 Aug;10(2):347-53. doi: 10.1128/AAC.10.2.347.
8
High-performance liquid chromatographic assay of chloramphenicol in serum.
Antimicrob Agents Chemother. 1978 Sep;14(3):439-43. doi: 10.1128/AAC.14.3.439.
9
Simplified radioenzymatic assay for chloramphenicol.
Antimicrob Agents Chemother. 1978 Jan;13(1):25-9. doi: 10.1128/AAC.13.1.25.
10
Central nervous system chloramphenicol concentration in premature infants.
Antimicrob Agents Chemother. 1978 Mar;13(3):427-9. doi: 10.1128/AAC.13.3.427.
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