Schill W B, Hofmann C, Plewig G
Arch Dermatol Res. 1979 Mar 31;264(2):153-60. doi: 10.1007/BF00431126.
In 9 male patients with psoriasis vulgaris a semen analysis before and during photochemotherapy with 8-methoxypsoralen and UVA (PUVA) was performed to rule out drug-induced toxic damage of spermatogenesis or impairment of fertility due to scrotal hyperthermia. Two hours after oral application of 40--60 mg 8-methoxypsoralen the patients had been irradiated in UVA high intensity treatment units. PUVA-treatments were performed four times weekly until total body clearing was achieved. For complete remission 13--26 (mean 20.5) PUVA-treatments were necessary. Corresponding total UVA-doses were 35.3--191.0 (mean 83.2) Joule/cm2. The investigated parameters total motility, progressive motility, spermatozoa density, total spermatozoa count, spermatozoa morphology, and seminal plasma fructose remained unchanged. Only the volume of the ejaculate showed a small decrease during 3 months of therapy. From this pilot study there is no evidence that PUVA-therapy leads to an impairment of fertility in male patients within their reproductive age.
对9名寻常型银屑病男性患者在使用8-甲氧基补骨脂素和紫外线A（PUVA）进行光化学疗法之前及治疗期间进行了精液分析，以排除药物引起的生精毒性损害或阴囊高温导致的生育能力受损。口服40 - 60毫克8-甲氧基补骨脂素两小时后，患者在高强度紫外线A治疗设备中接受照射。PUVA治疗每周进行4次，直至全身皮损清除。为实现完全缓解，需要进行13 - 26次（平均20.5次）PUVA治疗。相应的总紫外线A剂量为35.3 - 191.0（平均83.2）焦耳/平方厘米。所研究的参数，如总活力、前向运动力、精子密度、总精子数、精子形态和精浆果糖含量均保持不变。仅在治疗3个月期间，射精量略有减少。从这项初步研究来看，没有证据表明PUVA疗法会导致育龄男性患者的生育能力受损。
