人体摄入苄胺后马尿酸的排泄情况。
Hippuric acid excretion after benzylamine ingestion in man.
作者信息
Wood S G, Al-Ani M R, Lawson A
出版信息
Br J Ind Med. 1978 Aug;35(3):230-1. doi: 10.1136/oem.35.3.230.
Abstract
The fate of 14C-benzylamine after oral administration as the hydrochloride has been investigated in two male volunteers. Over 98% of the administered radiolabel was excreted in the urine as 14C-hippuric acid within 24 hours. The rate of urinary hippuric acid excretion was extremely rapid, with more than 90% of the dose excreted after three hours.
摘要
在两名男性志愿者中研究了口服盐酸盐形式的14C-苄胺后的命运。超过98%的给药放射性标记在24小时内以14C-马尿酸的形式随尿液排出。尿中马尿酸的排泄速度极快，三小时后超过90%的剂量被排出。
相似文献
1
Hippuric acid excretion after benzylamine ingestion in man.人体摄入苄胺后马尿酸的排泄情况。
Br J Ind Med. 1978 Aug;35(3):230-1. doi: 10.1136/oem.35.3.230.
2
The metabolism of saddamine in man: the fate of the benzylamine moiety of saddamine.沙达明在人体内的代谢：沙达明苄胺部分的去向。
Eur J Drug Metab Pharmacokinet. 1979;4(2):117-9. doi: 10.1007/BF03189411.
3
N-Methyl-benzylamine, a metabolite of pargyline in man.N-甲基苄胺，人身体中优降宁的一种代谢产物。
Br J Clin Pharmacol. 1979 Jun;7(6):595-8. doi: 10.1111/j.1365-2125.1979.tb04648.x.
4
Toxicokinetics of toluene and urinary excretion of hippuric acid after human exposure to 2H8-toluene.人体暴露于2H8-甲苯后甲苯的毒代动力学及马尿酸的尿排泄情况。
Br J Ind Med. 1993 Jan;50(1):55-9. doi: 10.1136/oem.50.1.55.
5
Metabolism of beclamide, N-benzyl-3-chloropropionamide, in man.
Xenobiotica. 1979 Feb;9(2):129-40. doi: 10.3109/00498257909038713.
6
Evaluation of liver function by co-administration methodology using 13C-labelled benzoic acid and hippuric acid coupled with nuclear magnetic resonance spectroscopy.使用13C标记的苯甲酸和马尿酸，结合核磁共振波谱法，通过联合给药方法评估肝功能。
J Pharm Pharmacol. 1997 Dec;49(12):1242-7. doi: 10.1111/j.2042-7158.1997.tb06078.x.
7
Reliability of urinary excretion rate adjustment in measurements of hippuric acid in urine.尿中马尿酸排泄率校正测量的可靠性。
Int J Environ Res Public Health. 2014 Jul 11;11(7):7036-44. doi: 10.3390/ijerph110707036.
8
Urinary hippuric acid after ingestion of edible fruits.食用水果后尿中的马尿酸
Bosn J Basic Med Sci. 2008 Feb;8(1):38-43. doi: 10.17305/bjbms.2008.2994.
9
Physiological disposition and metabolic fate of a new antiarrhythmic agent, alpha, alpha-dimethyl-4-(alpha, alpha, beta, beta-tetrafluorophenethyl) benzylamine in the rat, dog, monkey, baboon, and man.一种新型抗心律失常药物α,α-二甲基-4-(α,α,β,β-四氟苯乙基)苄胺在大鼠、狗、猴、狒狒和人体内的生理处置及代谢命运。
Drug Metab Dispos. 1976 Jul-Aug;4(4):387-401.
10
Urinary hippuric acid concentration after occupational exposure to toluene.职业性接触甲苯后尿中马尿酸浓度
Br J Ind Med. 1978 Nov;35(4):330-4. doi: 10.1136/oem.35.4.330.
引用本文的文献
1
Oral Supplementation with Benzylamine Delays the Onset of Diabetes in Obese and Diabetic db-/- Mice.苯甲胺口服补充可延缓肥胖和糖尿病 db-/- 小鼠糖尿病的发病。
Nutrients. 2021 Jul 29;13(8):2622. doi: 10.3390/nu13082622.
2
TLC separation of hippuric, mandelic, and phenylglyoxylic acids from urine after mixed exposure to toluene and styrene.甲苯和苯乙烯混合暴露后，从尿液中对马尿酸、扁桃酸和苯甲酰甲酸进行薄层色谱分离。
Br J Ind Med. 1982 May;39(2):187-90. doi: 10.1136/oem.39.2.187.
3
The metabolism of saddamine in man: the fate of the benzylamine moiety of saddamine.沙达明在人体内的代谢：沙达明苄胺部分的去向。
Eur J Drug Metab Pharmacokinet. 1979;4(2):117-9. doi: 10.1007/BF03189411.
本文引用的文献
1
Significance of urinary hippuric acid determination as an index of toluene exposure.尿马尿酸测定作为甲苯暴露指标的意义。
Br J Ind Med. 1969 Jul;26(3):244-6. doi: 10.1136/oem.26.3.244.
2
Urinary hippuric acid excretion as an index of toluene exposure.尿马尿酸排泄作为甲苯暴露的指标。
Am Ind Hyg Assoc J. 1967 Mar-Apr;28(2):129-34. doi: 10.1080/00028896709342496.
3
The fate of benzoic acid in various species.苯甲酸在不同物种中的命运。
Biochem J. 1970 Jun;118(1):47-51. doi: 10.1042/bj1180047.
Zotero 插件