氢化可的松对大鼠白细胞中前列腺素生物合成的抑制机制。
Mechanism of inhibition of prostaglandin biosynthesis by hydrocortisone in rat leucocytes.
作者信息
Di Rosa M, Persico P
出版信息
Br J Pharmacol. 1979 Jun;66(2):161-3. doi: 10.1111/j.1476-5381.1979.tb13659.x.
Abstract
Hydrocortisone (10 microgram/ml) greatly inhibits the prostaglandin release by rat peritoneal leucocytes phagocytosing killed bacteria. The inhibition, which occurs after an initial latency of 30 min, is completely reversed by either actinomycin D (0.5 microgram/ml) or cycloheximide (1 microgram/ml). Since these antibiotics are known inhibitors of DNA-dependent RNA synthesis and protein synthesis respectively, it appears that the mechanism of inhibition of prostaglandin biosynthesis by hydrocortisone in rat leucocytes involves stimulation of transcription and induction of protein synthesis.
摘要
氢化可的松（10微克/毫升）能显著抑制大鼠腹腔白细胞吞噬死菌后释放前列腺素。这种抑制作用在最初30分钟的潜伏期后出现，放线菌素D（0.5微克/毫升）或环己酰亚胺（1微克/毫升）均可完全逆转该抑制作用。由于已知这些抗生素分别是DNA依赖性RNA合成和蛋白质合成的抑制剂，因此氢化可的松对大鼠白细胞中前列腺素生物合成的抑制机制似乎涉及转录的刺激和蛋白质合成的诱导。
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A chemotactic role for prostaglandins released from polymorphonuclear leucocytes during phagocytosis.多形核白细胞在吞噬过程中释放的前列腺素的趋化作用。
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