氢化可的松对大鼠腹膜白细胞中前列腺素生物合成的抑制作用与细胞内巨皮质素水平相关。
The inhibition by hydrocortisone of prostaglandin biosynthesis in rat peritoneal leucocytes is correlated with intracellular macrocortin levels.
作者信息
Carnuccio R, Di Rosa M, Flower R J, Pinto A
出版信息
Br J Pharmacol. 1981 Oct;74(2):322-4. doi: 10.1111/j.1476-5381.1981.tb09974.x.
Abstract
Hydrocortisone inhibits prostaglandin generation by rat peritoneal leucocytes by releasing the polypeptide phospholipase inhibitor, macrocortin. The susceptibility of these cells to hydrocortisone is directly correlated with their intracellular macrocortin content. Cells depleted of the peptide by prior incubation with steroid cannot respond to the steroid, until a fresh intracellular store has been synthesized. In vitro, this process requires 4-5 h. Cells remain sensitive to the inhibitory action of the peptide at all times.
摘要
氢化可的松通过释放多肽磷脂酶抑制剂巨皮质素，抑制大鼠腹膜白细胞生成前列腺素。这些细胞对氢化可的松的敏感性与其细胞内巨皮质素含量直接相关。预先用类固醇孵育而耗尽该肽的细胞，在新的细胞内储存合成之前，无法对类固醇作出反应。在体外，这个过程需要4 - 5小时。细胞在任何时候都对该肽的抑制作用保持敏感。
相似文献
1
The inhibition by hydrocortisone of prostaglandin biosynthesis in rat peritoneal leucocytes is correlated with intracellular macrocortin levels.氢化可的松对大鼠腹膜白细胞中前列腺素生物合成的抑制作用与细胞内巨皮质素水平相关。
Br J Pharmacol. 1981 Oct;74(2):322-4. doi: 10.1111/j.1476-5381.1981.tb09974.x.
2
Hydrocortisone and 'macrocortin' inhibit the zymosan-induced release of lyso-PAF from rat peritoneal leucocytes.氢化可的松和“大皮质素”可抑制酵母聚糖诱导的大鼠腹腔白细胞中溶血血小板活化因子的释放。
Life Sci. 1985 Apr 1;36(13):1225-31. doi: 10.1016/0024-3205(85)90266-8.
3
Hydrocortisone-induced inhibitor of prostaglandin biosynthesis in rat leucocytes.氢化可的松诱导的大鼠白细胞中前列腺素生物合成抑制剂
Br J Pharmacol. 1980 Jan;68(1):14-6. doi: 10.1111/j.1476-5381.1980.tb10691.x.
4
Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids.巨皮质素：一种引起糖皮质激素抗磷脂酶作用的多肽。
Nature. 1980 Sep 11;287(5778):147-9. doi: 10.1038/287147a0.
5
Mechanism of inhibition of prostaglandin biosynthesis by hydrocortisone in rat leucocytes.氢化可的松对大鼠白细胞中前列腺素生物合成的抑制机制。
Br J Pharmacol. 1979 Jun;66(2):161-3. doi: 10.1111/j.1476-5381.1979.tb13659.x.
6
Latency and reversion of hydrocortisone inhibition of prostaglandin biosynthesis in rat leucocytes.氢化可的松对大鼠白细胞中前列腺素生物合成抑制作用的潜伏期及恢复情况
Agents Actions Suppl. 1979(4):63-72.
7
Specificity and inhibition of glucocorticoid-induced macrocortin secretion from rat peritoneal macrophages.糖皮质激素诱导大鼠腹腔巨噬细胞分泌巨皮质素的特异性及抑制作用
Br J Pharmacol. 1983 Jun;79(2):587-94. doi: 10.1111/j.1476-5381.1983.tb11033.x.
8
Failure of anti-inflammatory steroids to inhibit prostaglandin production by rat polymorphonuclear leucocytes.抗炎类固醇无法抑制大鼠多形核白细胞产生前列腺素。
Br J Pharmacol. 1980 Feb;68(2):199-205. doi: 10.1111/j.1476-5381.1980.tb10408.x.
9
The influence of ethanol on the synthesis of prostaglandin-like material by resident rat peritoneal cells from exogenous arachidonic acid.乙醇对大鼠腹膜常驻细胞利用外源性花生四烯酸合成类前列腺素物质的影响。
J Pharm Pharmacol. 1982 May;34(5):340-2. doi: 10.1111/j.2042-7158.1982.tb04723.x.
10
Inhibition of prostaglandin biosynthesis by corticosteroids.皮质类固醇对前列腺素生物合成的抑制作用。
Br Med J. 1972 Apr 8;2(5805):83-4. doi: 10.1136/bmj.2.5805.83.
引用本文的文献
1
The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil.膜联蛋白A1/甲酰肽受体2系统在调节化合物48/80引发的肥大细胞脱颗粒及奈多罗米抑制作用中的作用
Int Immunopharmacol. 2016 Mar;32:87-95. doi: 10.1016/j.intimp.2016.01.003. Epub 2016 Jan 21.
2
Macrophage migration inhibitory factor counter-regulates dexamethasone-induced annexin 1 expression and influences the release of eicosanoids in murine macrophages.巨噬细胞移动抑制因子负调控地塞米松诱导的膜联蛋白 1 表达并影响小鼠巨噬细胞中类花生酸的释放。
Immunology. 2013 Oct;140(2):250-8. doi: 10.1111/imm.12135.
3
Annexin-A1: a pivotal regulator of the innate and adaptive immune systems.膜联蛋白-A1：先天性和适应性免疫系统的关键调节因子。
Br J Pharmacol. 2008 Sep;155(2):152-69. doi: 10.1038/bjp.2008.252. Epub 2008 Jul 21.
4
Glucocorticoid-and non-glucocorticoid induction of lipocortins (annexins) 1 and 2 in rat peritoneal leucocytes in vivo.糖皮质激素和非糖皮质激素对大鼠体内腹膜白细胞中脂皮质素（膜联蛋白）1和2的诱导作用
Br J Pharmacol. 1993 Jan;108(1):66-72. doi: 10.1111/j.1476-5381.1993.tb13441.x.
5
Dexamethasone-induced translocation of lipocortin (annexin) 1 to the cell membrane of U-937 cells.地塞米松诱导脂皮质素（膜联蛋白）1转位至U-937细胞的细胞膜。
Br J Pharmacol. 1994 Jun;112(2):347-8. doi: 10.1111/j.1476-5381.1994.tb13075.x.
6
Dexamethasone increases the synthesis of sphingomyelin in 3T3-L1 cell membranes.地塞米松可增加3T3-L1细胞膜中鞘磷脂的合成。
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6690-2. doi: 10.1073/pnas.79.21.6690.
7
How is the level of free arachidonic acid controlled in mammalian cells?哺乳动物细胞中游离花生四烯酸的水平是如何控制的？
Biochem J. 1982 Apr 15;204(1):3-16. doi: 10.1042/bj2040003.
8
H-2 influences phenytoin binding and inhibition of prostaglandin synthesis.H - 2影响苯妥英钠的结合以及前列腺素合成的抑制。
Immunogenetics. 1984;20(6):667-76. doi: 10.1007/BF00430325.
9
Specificity and inhibition of glucocorticoid-induced macrocortin secretion from rat peritoneal macrophages.糖皮质激素诱导大鼠腹腔巨噬细胞分泌巨皮质素的特异性及抑制作用
Br J Pharmacol. 1983 Jun;79(2):587-94. doi: 10.1111/j.1476-5381.1983.tb11033.x.
10
Glucocorticoids induce the formation and release of anti-inflammatory and anti-phospholipase proteins into the peritoneal cavity of the rat.糖皮质激素可诱导抗炎和抗磷脂酶蛋白在大鼠腹腔内的形成与释放。
Br J Pharmacol. 1982 May;76(1):185-94. doi: 10.1111/j.1476-5381.1982.tb09205.x.
本文引用的文献
1
Hydrocortisone-induced inhibitor of prostaglandin biosynthesis in rat leucocytes.氢化可的松诱导的大鼠白细胞中前列腺素生物合成抑制剂
Br J Pharmacol. 1980 Jan;68(1):14-6. doi: 10.1111/j.1476-5381.1980.tb10691.x.
2
A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.糖皮质激素诱导的兔中性粒细胞中的一种磷脂酶A2抑制蛋白。
Proc Natl Acad Sci U S A. 1980 May;77(5):2533-6. doi: 10.1073/pnas.77.5.2533.
3
Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids.巨皮质素：一种引起糖皮质激素抗磷脂酶作用的多肽。
Nature. 1980 Sep 11;287(5778):147-9. doi: 10.1038/287147a0.
4
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.抑制前列腺素合成作为阿司匹林类药物的作用机制。
Nat New Biol. 1971 Jun 23;231(25):232-5. doi: 10.1038/newbio231232a0.
5
Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitized guinea pig.皮质类固醇抑制前列腺素从兔灌注肠系膜血管和致敏豚鼠灌注肺中释放。
Prostaglandins. 1975 Aug;10(2):343-55. doi: 10.1016/0090-6980(75)90053-2.
6
Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.抑制细胞中花生四烯酸的释放作为抗炎皮质类固醇的生化作用。
Proc Natl Acad Sci U S A. 1976 May;73(5):1730-4. doi: 10.1073/pnas.73.5.1730.
7
Effects of anti-inflammatory drugs on macrophage prostaglandin biosynthesis [proceedings].抗炎药物对巨噬细胞前列腺素生物合成的影响[会议论文集]
Br J Pharmacol. 1976 Jul;57(3):466P-467P.
8
Partial purification of rabbit aorta contracting substance-releasing factor and inhibition of its activity by anti-inflammatory steroids.兔主动脉收缩物质释放因子的部分纯化及其活性受抗炎类固醇的抑制作用
Nature. 1976 Oct 7;263(5577):479-82. doi: 10.1038/263479a0.
9
Phospholipase A2 activity of guinea-pig isolated perfused lungs: stimulation, and inhibition by anti-inflammatory steroids.豚鼠离体灌注肺的磷脂酶A2活性：抗炎类固醇的刺激和抑制作用
Br J Pharmacol. 1978 Jan;62(1):79-89. doi: 10.1111/j.1476-5381.1978.tb07009.x.
10
Mechanism of inhibition of prostaglandin biosynthesis by hydrocortisone in rat leucocytes.氢化可的松对大鼠白细胞中前列腺素生物合成的抑制机制。
Br J Pharmacol. 1979 Jun;66(2):161-3. doi: 10.1111/j.1476-5381.1979.tb13659.x.
Zotero 插件