系统性红斑狼疮免疫发病机制的最新进展
Recent advances in the immunopathogenesis of systemic lupus erythematosus.
作者信息
Bardana E J, Pirofsky B
出版信息
West J Med. 1975 Feb;122(2):130-44.
Abstract
Systemic lupus erythematosus (SLE) is a chronic multisystem inflammatory disease having definite etiologic associations with ethnic, genetic, viral and immunologic factors. Its pathologic hallmark, vasculitis, is currently felt to be the end result of an immune-complex mechanism. Several clinical and serologic variants of SLE are recognized including discoid lupus erythematosus (DLE), mixed connective tissue disease (MCTD) and drug-induced equivalents-such as procainamide-induced lupus (PIL). The distinguishing features of these variants as well as their prognosis and therapy are discussed in relation to recent developments in the immunopathogenesis of SLE.
摘要
系统性红斑狼疮（SLE）是一种慢性多系统炎症性疾病，与种族、遗传、病毒和免疫因素有明确的病因学关联。其病理标志——血管炎，目前被认为是免疫复合物机制的最终结果。SLE有几种临床和血清学变体，包括盘状红斑狼疮（DLE）、混合性结缔组织病（MCTD）以及药物诱导的类似病症，如普鲁卡因胺诱导的狼疮（PIL）。结合SLE免疫发病机制的最新进展，讨论了这些变体的显著特征及其预后和治疗方法。
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