膳食纤维与结肠肿瘤
Dietary fibre and colonic neoplasia.
作者信息
Freeman H J
出版信息
Can Med Assoc J. 1979 Aug 4;121(3):291-6.
Dietary plant fibre, or plantix, is thought to play a significant role in the pathogenesis of colon cancer in humans. It is a complex polymeric substance that has several distinct components resistant to hydrolysis by the digestive enzymes of humans. These components include cellulose, hemicelluloses, pectins, lignin, gums, mucilages and, in certain instances, algal polysaccharides. These polymers have different physicochemical properties, and recent evidence from experimental studies in animals treated with carcinogens suggests that some may exert protective effects in the intestine and others may enhance colon carcinogenesis. This review synthesizes information on the chemical composition, methods of analysis and physicochemical properties of dietary plant fibre and reviews available studies examining the role of fibre in colonic neoplasia in animals and humans.
膳食植物纤维，即植素，被认为在人类结肠癌的发病机制中起重要作用。它是一种复杂的聚合物质，有几种不同的成分能抵抗人类消化酶的水解作用。这些成分包括纤维素、半纤维素、果胶、木质素、树胶、黏液质，在某些情况下还包括藻类多糖。这些聚合物具有不同的物理化学性质，最近对用致癌物处理的动物进行的实验研究证据表明，有些可能在肠道中发挥保护作用，而另一些可能会促进结肠癌的发生。这篇综述综合了关于膳食植物纤维的化学成分、分析方法和物理化学性质的信息，并回顾了现有的研究，这些研究探讨了纤维在动物和人类结肠肿瘤形成中的作用。
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