血清中庆大霉素的四小时微生物学测定
Four-hour microbiological assay of gentamicin in serum.
作者信息
Warren E, Snyder R J, Washington JA I I
出版信息
Antimicrob Agents Chemother. 1972 Jan;1(1):46-8. doi: 10.1128/AAC.1.1.46.
Abstract
Since the microbiological assay of the antibiotic content of serum generally requires 18 to 24 hr of incubation, results of such procedures may not become available in time to make appropriate adjustments in subsequent dosages of antibiotic. A 4-hr bioassay for determining concentrations of gentamicin in serum has been developed in which Staphylococcus aureus ATCC 6538P is used as the test organism. Poured plates have yielded satisfactory results after storage at 4 C for 5 days. Results of the 4-hr procedure agree closely with those of a conventional 18-hr disc-plate assay performed with the same test organism.
摘要
由于血清中抗生素含量的微生物学测定通常需要18至24小时的培养时间，因此此类检测结果可能无法及时获得，以便对后续抗生素剂量进行适当调整。已开发出一种用于测定血清中庆大霉素浓度的4小时生物测定法，其中使用金黄色葡萄球菌ATCC 6538P作为测试菌株。倾注平板在4℃储存5天后产生了满意的结果。4小时检测程序的结果与使用相同测试菌株进行的传统18小时纸片平板检测结果非常吻合。
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J Clin Pathol. 1969 Sep;22(5):534-8. doi: 10.1136/jcp.22.5.534.
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