Rabinovich S
Antimicrob Agents Chemother. 1972 May;1(5):408-11. doi: 10.1128/AAC.1.5.408.
Eighty per cent of mice infected with a mouse-adapted strain of influenza virus died within 3 to 8 days after infection. Rimantadine given at maximum protective doses reduced mortality to 10%. This protection is dose related and can be demonstrated with doses from 4.5 to 24 mg per kg per day. Significant survival rates are shown by delaying treatment as long as 48 hr after infection. Lungs of treated mice have significantly less virus than those of controls at 24, 48, and 72 hr after infection. Antibody production as measured by hemagglutination inhibition is not different in treated and controlled mice. These results indicate that rimantadine is an effective prophylactic and therapeutic agent and that its activity is associated with decreased viral titers.
感染了鼠适应株流感病毒的小鼠，80%在感染后3至8天内死亡。给予最大保护剂量的金刚烷胺可将死亡率降至10%。这种保护作用与剂量相关，每天每公斤4.5至24毫克的剂量均可显示出该作用。感染后长达48小时延迟治疗仍可显示出显著的存活率。感染后24、48和72小时，接受治疗小鼠的肺部病毒量明显少于对照组。通过血凝抑制测定的抗体产生在治疗组和对照组小鼠中并无差异。这些结果表明金刚烷胺是一种有效的预防和治疗药物，其活性与病毒滴度降低有关。
