Krishan A, Frei E
Cancer Res. 1975 Mar;35(3):497-501.
Exposure of human leukemic lymphoblasts in suspension cultures to low concentrations of vinblastine and vincristine results in alterations in cell shape and leads to the formation and release of a large number of membrane-lined vesicles from the cytoplasm. Separation of these vesicles from peripheral cytoplasm is effected through alignment and fusion of small vacoules. Similar vesicle formation is seen neither in fibroblasts exposed to vinblastine nor in lymphoblasts exposed to bleomycin or adriamycin. Possible relation of this phenomenon to vinblastine- and vincristine-induced cytotoxicity, spherocytosis, and thrombocytosis is discussed.
悬浮培养的人白血病淋巴母细胞暴露于低浓度长春花碱和长春新碱会导致细胞形态改变，并促使大量有膜包被的囊泡从细胞质中形成并释放出来。这些囊泡与外周细胞质的分离是通过小液泡的排列和融合实现的。在暴露于长春花碱的成纤维细胞或暴露于博来霉素或阿霉素的淋巴母细胞中均未观察到类似的囊泡形成。本文讨论了这种现象与长春花碱和长春新碱诱导的细胞毒性、球形红细胞增多症及血小板增多症之间可能存在的关系。
