Auchincloss J H, Gilbert R, Kuppinger M, Peppi D, Teperow-Putter K
J Appl Physiol Respir Environ Exerc Physiol. 1979 Jun;46(6):1132-7. doi: 10.1152/jappl.1979.46.6.1132.
Treadmill exercise responses of oxygen uptake (VO2), CO2 production (VCO2), and venoarterial CO2 difference (Cv-Ca), measured by CO2 rebreathing (Defares technique) at 1 and 3 min of exercise, were studied in two separate series of control (apparently healthy) and coronary artery disease (CAD) subjects. In the 1-min series there were 21 controls and 15 CAD subjects. In the 3-min series there were 21 controls and 18 CAD subjects. All were males, ages 30--60 yr, and the CAD subjects had histories of myocardial infarction. In both series VO2 at 1 min and power requirement (P ) = 1,000 (VO2-1-1,000) was estimated where P =weight (kg) X grade (fractional) X walking speed (m/min). In the 1-min series (P = 1,000) all measurements were made at 45--60 s in separate test runs. In the 3-min series P was 750 kg.m/min, VCO2 and VO2 were measured at 2.5--3 min exercise, and Cv-Ca was measured at 3--3.25 min in the same test run. Data indicate that the average cardiac output (Q) for control subjects was 15 l/min in both series with lower values for CAD subjects. At 1 min reduced Q was accompanied by reduced VO2 or VCO2 and increased Cv-Ca, whereas at 3 min reduced Q was accompanied by increased Cv-Ca.
在两个独立的对照组（貌似健康者）和冠状动脉疾病（CAD）受试者系列中，研究了通过二氧化碳再呼吸法（德法雷斯技术）在运动1分钟和3分钟时测量的跑步机运动时的摄氧量（VO2）、二氧化碳产生量（VCO2）和静脉动脉二氧化碳分压差（Cv-Ca）。在1分钟系列中有21名对照组受试者和15名CAD受试者。在3分钟系列中有21名对照组受试者和18名CAD受试者。所有受试者均为男性，年龄在30至60岁之间，CAD受试者有心肌梗死病史。在两个系列中，均根据公式P =体重（kg）×坡度（分数）×步行速度（m/min）估算1分钟时的VO2和功率需求（P）= 1,000（VO2 - 1 - 1,000）。在1分钟系列中（P = 1,000），所有测量均在单独的测试运行中于45至60秒时进行。在3分钟系列中，P为750 kg·m/min，在运动2.5至3分钟时测量VCO2和VO2，并在同一次测试运行中的3至3.25分钟时测量Cv-Ca。数据表明，在两个系列中，对照组受试者的平均心输出量（Q）均为15 l/min，CAD受试者的值较低。在1分钟时，Q降低伴随着VO2或VCO2降低以及Cv-Ca升高，而在3分钟时，Q降低伴随着Cv-Ca升高。
