Zimmerman P, Heigenhauser G J, McCartney N, Sutton J R, Jones N L
J Appl Physiol Respir Environ Exerc Physiol. 1982 Jan;52(1):71-8. doi: 10.1152/jappl.1982.52.1.71.
The responses to two levels of exercise (400 and 800 kpm/min) were studied in nine untrained healthy subjects and seven patients with coronary artery disease. Measurements were made over 20-s time intervals to obtain the half times (t1/2) of the asymptotic rise in cardiac frequency (fc), O2 intake (VO2), CO2 output (VCO2), and ventilation (VE). Complete data were obtained in both groups at 400 kpm/min, but only in healthy subjects at 800 kpm/min, as patients were unable to exercise for longer than 2 min at this power. At the onset of 400 kpm/min, t1/2 for VO2 was similar, but t1/2 for fc, VCO2, and VE were all longer in the patients. At 800 kpm/min there was a delay in VO2 in the patients before stopping exercise. In patients and healthy subjects t1/2 for VCO2 and VE, but not VO2, were related to t1/2 for fc. The results emphasized the importance of tissue CO2 storage in attenuating the delivery of CO2 to the lungs and thus delayed the ventilatory response to a step increase in power output.
对9名未经训练的健康受试者和7名冠心病患者进行了两种运动强度（400和800 kpm/min）的反应研究。每隔20秒进行测量，以获取心率（fc）、氧气摄入量（VO2）、二氧化碳排出量（VCO2）和通气量（VE）渐近上升的半衰期（t1/2）。两组在400 kpm/min时均获得了完整数据，但在800 kpm/min时仅在健康受试者中获得，因为患者在此功率下无法运动超过2分钟。在400 kpm/min运动开始时，VO2的t1/2相似，但患者的fc、VCO2和VE的t1/2均更长。在800 kpm/min时，患者在停止运动前VO2出现延迟。在患者和健康受试者中，VCO2和VE的t1/2与fc的t1/2相关，但VO2的t1/2与fc的t1/2不相关。结果强调了组织二氧化碳储存对于减少二氧化碳向肺部输送的重要性，从而延迟了对功率输出阶跃增加的通气反应。
