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1
Comparative studies of the hepatocarcinogen N,N-dimethylnitrosamine in vivo: reaction sites in rat liver DNA and the significance of their relative stabilities.体内肝癌致癌物N，N-二甲基亚硝胺的比较研究：大鼠肝脏DNA中的反应位点及其相对稳定性的意义。
Br J Cancer. 1973 Feb;27(2):153-66. doi: 10.1038/bjc.1973.19.
2
The stability of rat liver ribonucleic acid in vivo after methylation with methyl methanesulphonate or dimethylnitrosamine.用甲磺酸甲酯或二甲基亚硝胺甲基化后大鼠肝脏核糖核酸在体内的稳定性
Biochem J. 1971 Dec;125(3):821-7. doi: 10.1042/bj1250821.
3
Differences in the patterns of methylation in rat liver ribosomal ribonucleic acid after reaction in vivo with methyl methanesulphonate and NN-dimethylnitrosamine.大鼠肝脏核糖体核糖核酸在体内与甲磺酸甲酯和N,N-二甲基亚硝胺反应后甲基化模式的差异。
Biochem J. 1972 Sep;129(3):519-28. doi: 10.1042/bj1290519.
4
Methylation of nuclear proteins by dimethylnitrosamine and by methionine in the rat in vivo.大鼠体内二甲基亚硝胺和蛋氨酸对核蛋白的甲基化作用。
Biochem J. 1971 Oct;124(4):725-39. doi: 10.1042/bj1240725.
5
Nitrosamine-induced carcinogenesis. The alklylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate.亚硝胺诱导的致癌作用。N-甲基-N-亚硝基脲、二甲基亚硝胺、硫酸二甲酯和甲磺酸甲酯对大鼠核酸的烷基化作用。
Biochem J. 1968 Nov;110(1):39-47. doi: 10.1042/bj1100039.
6
Effect of administration of the carcinogen dimethylnitrosamine on urinary 7-methylguanine.给予致癌物二甲基亚硝胺对尿中7-甲基鸟嘌呤的影响。
Biochem J. 1967 Aug;104(2):435-40. doi: 10.1042/bj1040435.
7
The pattern of methylated purines formed in DNA of intact and regenerating liver of rats treated with the carcinogen dimethylnitrosamine.用致癌物二甲基亚硝胺处理的大鼠完整肝脏和再生肝脏DNA中形成的甲基化嘌呤模式。
Biochim Biophys Acta. 1973 Jun 23;312(2):202-10. doi: 10.1016/0005-2787(73)90365-1.
8
The induction of chromosomal damage in rat hepatocytes and lymphocytes. II. Alkylation damage and repair of rat-liver DNA after diethylnitrosamine, dimethylnitrosamine and ethyl methanesulphonate in relation to clastogenic effects.大鼠肝细胞和淋巴细胞中染色体损伤的诱导。II. 二乙基亚硝胺、二甲基亚硝胺和甲磺酸乙酯作用后大鼠肝脏DNA的烷基化损伤与修复及其与致断裂效应的关系
Mutat Res. 1983 Jan;107(1):153-66. doi: 10.1016/0027-5107(83)90085-4.
9
Alkylation of DNA and tissue specificity in nitrosamine carcinogenesis.亚硝胺致癌作用中DNA的烷基化与组织特异性
J Supramol Struct Cell Biochem. 1981;17(3):259-73. doi: 10.1002/jsscb.380170307.
10
Persistence of methylated bases in ribonucleic acid of syrian golden hamster liver after administration of dimethylnitrosamine.给予二甲基亚硝胺后叙利亚金仓鼠肝脏核糖核酸中甲基化碱基的持久性。
Biochem J. 1979 Mar 1;177(3):967-73. doi: 10.1042/bj1770967.

引用本文的文献

1
Interaction of chemical carcinogens with macromolecules.化学致癌物与大分子的相互作用。
J Cancer Res Clin Oncol. 1981;99(1-2):167-86. doi: 10.1007/BF00412452.
2
Repair of O6-ethylguanine in DNA by a chromatin fraction from rat liver: transfer of the ethyl group to an acceptor protein.大鼠肝脏染色质组分对DNA中O6-乙基鸟嘌呤的修复：乙基向受体蛋白的转移
Proc Natl Acad Sci U S A. 1981 Nov;78(11):6766-70. doi: 10.1073/pnas.78.11.6766.
3
Nucleic acid adducts of chemical carcinogens and mutagens.化学致癌物和诱变剂的核酸加合物
Arch Toxicol. 1983 Apr;52(4):249-85. doi: 10.1007/BF00316495.
4
Urinary excretion of methylated purines following inhalation of dimethyl sulphate.吸入硫酸二甲酯后甲基化嘌呤的尿排泄情况。
Experientia. 1974 Jun 15;30(6):641-2. doi: 10.1007/BF01921519.
5
Cellular reactions of O6-methylguanine, a product of some alkylating carcinogens.某些烷基化致癌物的产物O6-甲基鸟嘌呤的细胞反应。
Biochem J. 1973 Oct;136(2):387-93. doi: 10.1042/bj1360387.
6
Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea.大鼠脑DNA中O6-乙基鸟嘌呤的持久性：与乙基亚硝基脲诱导的神经系统特异性致癌作用的相关性。
Proc Natl Acad Sci U S A. 1974 Mar;71(3):639-43. doi: 10.1073/pnas.71.3.639.
7
Reaction of methyl methanesulphonate with nucleic acids of fetal and newborn rats in vivo.甲磺酸甲酯与新生大鼠和胎鼠核酸在体内的反应。
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;81(3-4):273-83. doi: 10.1007/BF00305030.
8
Additive effect in the induction of kidney tumours in rats treated with dimethylnitrosamine and ethylmethanesulphonate.二甲基亚硝胺和甲磺酸乙酯处理的大鼠肾肿瘤诱导中的相加效应。
Br J Cancer. 1974 Jan;29(1):50-8. doi: 10.1038/bjc.1974.6.
9
Molecular and cellular mechanisms associated with pulse-carcinogenesis in the rat nerbous system by ethyinitrosourea: ethylation of nucleic acids and elimination rates of ethylated bases from the DNA of different tissues.乙基亚硝基脲诱导大鼠神经系统脉冲致癌作用的分子和细胞机制：核酸的乙基化及不同组织DNA中乙基化碱基的消除速率
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;82(1):37-64. doi: 10.1007/BF00304382.
10
Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli.大肠杆菌O6-烷基鸟嘌呤-DNA烷基转移酶基因ogt的特性与核苷酸序列
Nucleic Acids Res. 1987 Nov 25;15(22):9177-93. doi: 10.1093/nar/15.22.9177.

本文引用的文献

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CARCINOGENESIS STUDY WITH DIMETHYLNITROSAMINE ADMINISTERED ORALLY TO ADULT AND SUBCUTANEOUSLY TO NEWBORN BALB-C MICE.对成年BALB - C小鼠经口给予二甲基亚硝胺、对新生BALB - C小鼠皮下给予二甲基亚硝胺的致癌性研究。
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2
REACTION OF THE CARCINOGEN DIMETHYLNITROSAMINE WITH NUCLEIC ACIDS IN VIVO.致癌物二甲基亚硝胺在体内与核酸的反应。
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FURTHER STUDIES ON THE ALKYLATION OF NUCLEIC ACIDS AND THEIR CONSTITUENT NUCLEOTIDES.核酸及其组成核苷酸烷基化的进一步研究
Biochem J. 1963 Oct;89(1):127-38. doi: 10.1042/bj0890127.
4
"Lifespan" of liver cells. Autoradio-graphic study using tritiated thymidine in normal, cirrhotic, and partially hepatectomized rats.肝细胞的“寿命”。使用氚标记胸腺嘧啶核苷对正常、肝硬化和部分肝切除大鼠进行的放射自显影研究。
Arch Intern Med. 1961 Mar;107:335-43. doi: 10.1001/archinte.1961.03620030023003.
5
The production of malignant primary hepatic tumours in the rat by feeding dimethylnitrosamine.通过喂食二甲基亚硝胺在大鼠体内诱发原发性恶性肝肿瘤。
Br J Cancer. 1956 Mar;10(1):114-22. doi: 10.1038/bjc.1956.15.
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Studies on the action of diazomethane on deoxyribonucleic acid. The action of diazomethane on deoxyribonucleosides.重氮甲烷对脱氧核糖核酸作用的研究。重氮甲烷对脱氧核糖核苷的作用。
Biochim Biophys Acta. 1965 Jun 8;103(2):286-97. doi: 10.1016/0005-2787(65)90168-1.
7
Chemical modification of viral ribonucleic acid. 8. The chemical and biological effects of methylating agents and nitrosoguanidine on tobacco mosaic virus.病毒核糖核酸的化学修饰。8. 甲基化剂和亚硝基胍对烟草花叶病毒的化学及生物学效应。
Biochemistry. 1969 Aug;8(8):3266-9. doi: 10.1021/bi00836a020.
8
Possible relevance of O-6 alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides.脱氧鸟苷的O-6烷基化与亚硝胺和亚硝酰胺的致突变性和致癌性之间可能存在的关联。
Nature. 1969 Jul 12;223(5202):206-7. doi: 10.1038/223206a0.
9
Methylated bases in liver acids from rats treated with dimethylnitrosamine.用二甲基亚硝胺处理的大鼠肝脏酸中的甲基化碱基。
Biochim Biophys Acta. 1968 May 21;157(3):646-8. doi: 10.1016/0005-2787(68)90167-6.
10
Ribonucleic acid polymerase reactions with methylated polycytidylic acid templates.核糖核酸聚合酶与甲基化聚胞苷酸模板的反应。
J Biol Chem. 1968 May 25;243(10):2750-3.

体内肝癌致癌物N，N-二甲基亚硝胺的比较研究：大鼠肝脏DNA中的反应位点及其相对稳定性的意义。

Comparative studies of the hepatocarcinogen N,N-dimethylnitrosamine in vivo: reaction sites in rat liver DNA and the significance of their relative stabilities.

作者信息

O'Connor P J, Capps M J, Craig A W

出版信息

Br J Cancer. 1973 Feb;27(2):153-66. doi: 10.1038/bjc.1973.19.

DOI:10.1038/bjc.1973.19
PMID:4694387
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2008841/
Abstract

The reaction of the hepatocarcinogen N,N-dimethylnitrosamine has been compared with that of methyl methanesulphonate, a methylating agent which is not a liver carcinogen. Consistent differences have been observed in the reaction of rat liver DNA in vivo with these agents; O(6)-alkylation and the production of unidentified acid-labile products were distinctive features of the reaction with the carcinogenic nitroso compound but were undetectable or in low yield, respectively, after reaction with the alkyl sulphonate. Evidence has been obtained for the excision of these reaction products in animals treated with the hepatocarcinogen and the significance of their relative stabilities is discussed.

摘要

已将肝癌致癌物N，N-二甲基亚硝胺的反应与甲磺酸甲酯（一种非肝脏致癌物的甲基化剂）的反应进行了比较。在大鼠肝脏DNA体内与这些试剂的反应中观察到了一致的差异；O(6)-烷基化和未鉴定的酸不稳定产物的产生是与致癌亚硝基化合物反应的显著特征，但与烷基磺酸盐反应后分别无法检测到或产量很低。已获得在用肝癌致癌物处理的动物中切除这些反应产物的证据，并讨论了它们相对稳定性的意义。