体内肝癌致癌物N，N-二甲基亚硝胺的比较研究：大鼠肝脏DNA中的反应位点及其相对稳定性的意义。
Comparative studies of the hepatocarcinogen N,N-dimethylnitrosamine in vivo: reaction sites in rat liver DNA and the significance of their relative stabilities.
作者信息
O'Connor P J, Capps M J, Craig A W
出版信息
Br J Cancer. 1973 Feb;27(2):153-66. doi: 10.1038/bjc.1973.19.
Abstract
The reaction of the hepatocarcinogen N,N-dimethylnitrosamine has been compared with that of methyl methanesulphonate, a methylating agent which is not a liver carcinogen. Consistent differences have been observed in the reaction of rat liver DNA in vivo with these agents; O(6)-alkylation and the production of unidentified acid-labile products were distinctive features of the reaction with the carcinogenic nitroso compound but were undetectable or in low yield, respectively, after reaction with the alkyl sulphonate. Evidence has been obtained for the excision of these reaction products in animals treated with the hepatocarcinogen and the significance of their relative stabilities is discussed.
摘要
已将肝癌致癌物N，N-二甲基亚硝胺的反应与甲磺酸甲酯（一种非肝脏致癌物的甲基化剂）的反应进行了比较。在大鼠肝脏DNA体内与这些试剂的反应中观察到了一致的差异；O(6)-烷基化和未鉴定的酸不稳定产物的产生是与致癌亚硝基化合物反应的显著特征，但与烷基磺酸盐反应后分别无法检测到或产量很低。已获得在用肝癌致癌物处理的动物中切除这些反应产物的证据，并讨论了它们相对稳定性的意义。
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