Hartmann E, Spinweber C L
J Nerv Ment Dis. 1979 Aug;167(8):497-9.
Previous results have demonstrated sleep-inducing effects of L-tryptophan in doses of 1 to 15 g at bedtime. The present laboratory study extends the dose-response curve downward, comparing doses of 1/4 g, 1/2 g, and 1 g of L-tryptophan with placebo, in 15 mild insomniacs (subjects who reported sleep latencies of over 30 minutes). One gram of L-tryptophan significantly reduced sleep latency: the lower doses produced a trend in the same direction. Stage IV sleep was significantly increased by 1/4 g of L-tryptophan. These results at low doses have interesting implications since the normal dietary intake of L-tryptophan is 1/2 g to 2 g per day.
先前的研究结果表明，睡前服用1至15克剂量的L-色氨酸具有诱导睡眠的作用。本实验室研究将剂量反应曲线向下延伸，在15名轻度失眠者（报告睡眠潜伏期超过30分钟的受试者）中，将1/4克、1/2克和1克的L-色氨酸剂量与安慰剂进行比较。1克L-色氨酸显著缩短了睡眠潜伏期：较低剂量也呈现出相同的趋势。1/4克L-色氨酸使第四阶段睡眠显著增加。低剂量的这些结果具有有趣的意义，因为L-色氨酸的正常饮食摄入量为每天1/2克至2克。
