Lancet. 1975 Mar 1;1(7905):478-80.
Green-tobacco sickness is an occupational illness of tobacco harvesters. Symptoms include nausea, vomiting, dizziness, and prostration. The disease is self-limited and of short duration, but recurs frequently in susceptible workers. The aetiology is not known, but nicotine has been suspected as a causative agent. Thirty-two workers on four North Carolina tobacco farms were studied during harvesting. None of these workers smoked or chewed tobacco. Urinary cotinine (the major metabolite of nicotine) levels were monitored over a 24-hour period to evaluate nicotine absorption. There was a tenfold rise in mean excretion of cotinine among workers who had greatest contact with the tobacco. Less cotinine was found in urine of workers who had less exposure. Levels of cotinine exceeded those found in novice smokers who smoked 3 cigarettes in succession. Absorption of nicotine from tobacco leaf is the likely cause of tobacco sickness.
绿烟草病是烟草采摘工人的一种职业病。症状包括恶心、呕吐、头晕和虚脱。该病为自限性，病程较短，但易感工人常反复发病。病因不明，但尼古丁被怀疑是致病因素。在北卡罗来纳州的四个烟草农场，对32名工人在收获季节进行了研究。这些工人均不吸烟或嚼烟草。在24小时内监测尿可替宁（尼古丁的主要代谢产物）水平，以评估尼古丁吸收情况。与烟草接触最多的工人，其可替宁平均排泄量增加了10倍。接触较少的工人尿液中可替宁含量较低。可替宁水平超过了连续吸3支烟的新手吸烟者。从烟叶中吸收尼古丁可能是烟草病的病因。
