Onuki Mayumi, Yokoyama Kazuhito, Kimura Kaoru, Sato Hajime, Nordin Rusli Bin, Naing Lin, Morita Yoko, Sakai Tadashi, Kobayashi Yasuki, Araki Shunichi
Department of Public Health, Graduate School of Medicine, The University of Tokyo, Japan.
J Occup Health. 2003 May;45(3):140-5. doi: 10.1539/joh.45.140.
To assess dermal absorption of nicotine from tobacco leaves in relation to Green Tobacco Sickness (GTS), urinary cotinine concentrations were measured in 80 male tobacco-growing farmers and in 40 healthy males (controls) who did not handle wet tobacco leaves in Kelantan, Malaysia. Among non-smokers, urinary cotinine levels in farmers were significantly higher than those of controls; farmers with urinary cotinine of 50 ng/ml/m2 or above showed eye symptoms more frequently than those below this level (p<0.05). Farmers who did not wear protective equipment had subjective symptoms more frequently than those who used the equipment (p<0.05); some of these symptoms were seen more frequently in organophosphate (Tamaron) users than in non-users. As tobacco farmers evidence a risk of nicotine poisoning from tobacco leaves, assessment including GTS together with effects of pesticides will be necessary.
为评估烟草叶片中尼古丁的皮肤吸收与绿烟草病（GTS）的关系，对马来西亚吉兰丹州80名种植烟草的男性农民和40名未接触过湿烟叶的健康男性（对照组）的尿可替宁浓度进行了测量。在不吸烟者中，农民的尿可替宁水平显著高于对照组；尿可替宁水平在50 ng/ml/m²及以上的农民比低于该水平的农民眼部症状更频繁（p<0.05）。未穿戴防护装备的农民比使用该装备的农民主观症状更频繁（p<0.05）；其中一些症状在使用有机磷农药（稻丰散）的农民中比未使用者中更频繁出现。由于烟农存在因烟叶导致尼古丁中毒的风险，有必要进行包括GTS以及农药影响的评估。
