Low-Beer T S, Heaton K W, Pomare E W, Read A E
Gut. 1973 Mar;14(3):204-8. doi: 10.1136/gut.14.3.204.
The size and composition of the bile salt pool has been measured in patients with untreated coeliac disease and in control subjects. The total bile salt pool was markedly increased in coeliac patients, the average being 9.2 grams compared with 3.1 grams in controls. Taurocholate synthesis was normal, consistent with its enlarged pool and prolonged half-life. Half-life and pool size were significantly correlated. The composition of the bile salt pool was virtually identical in the two groups. Our findings suggest that as the enterohepatic circulation is slowed by gallbladder inertia, so hepatic surveillance of pool size is diminished.
已对未经治疗的乳糜泻患者和对照受试者的胆盐池大小及成分进行了测量。乳糜泻患者的总胆盐池显著增加，平均为9.2克，而对照组为3.1克。牛磺胆酸盐合成正常，与其扩大的胆盐池和延长的半衰期一致。半衰期和胆盐池大小显著相关。两组胆盐池的成分几乎相同。我们的研究结果表明，由于胆囊惰性导致肠肝循环减慢，肝脏对胆盐池大小的监测也会减弱。
