• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

在糖异生条件下肝脏L-丝氨酸-丙酮酸转氨酶活性增加。

Increased liver L-serine-pyruvate aminotransferase activity under gluconeogenic conditions.

作者信息

Rowsell E V, al-Tai A H, Carnie J A

出版信息

Biochem J. 1973 May;134(1):349-51. doi: 10.1042/bj1340349.

DOI:10.1042/bj1340349
PMID:4723229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1177815/
Abstract

Rat liver l-serine-pyruvate aminotransferase activity exceeds markedly the normal adult value (a) in the neonatal period, (b) after glucagon injection and (c) after alloxan injection, observations that reinforce the suggestion from comparative findings that the aminotransferase has a role in gluconeogenesis. Some findings, however, argue in favour of l-serine dehydratase as the enzyme of gluconeogenesis from l-serine.

摘要

大鼠肝脏L-丝氨酸-丙酮酸转氨酶活性在以下情况下显著超过正常成年值:(a) 新生儿期;(b) 注射胰高血糖素后;(c) 注射四氧嘧啶后。这些观察结果进一步支持了比较研究结果所提出的观点,即该转氨酶在糖异生过程中起作用。然而,一些研究结果支持L-丝氨酸脱水酶是L-丝氨酸糖异生的酶。

相似文献

1
Increased liver L-serine-pyruvate aminotransferase activity under gluconeogenic conditions.在糖异生条件下肝脏L-丝氨酸-丙酮酸转氨酶活性增加。
Biochem J. 1973 May;134(1):349-51. doi: 10.1042/bj1340349.
2
Regulation of hepatic L-serine dehydratase and L-serine-pyruvate aminotransferase in the developing neonatal rat.新生大鼠发育过程中肝脏L-丝氨酸脱水酶和L-丝氨酸-丙酮酸转氨酶的调节
Biochem J. 1974 Dec;144(3):519-31. doi: 10.1042/bj1440519.
3
Mitochondrial-cytosolic interrelationships involved in gluconeogenesis from serine in rat liver.大鼠肝脏中丝氨酸糖异生过程中线粒体与胞质的相互关系。
FEBS Lett. 1975 Jul 15;55(1):202-5. doi: 10.1016/0014-5793(75)80992-6.
4
Gluconeogenesis from serine by the serine-dehydratase-dependent pathway in rat liver.大鼠肝脏中通过丝氨酸脱水酶依赖性途径由丝氨酸进行的糖异生作用。
Eur J Biochem. 1974 Apr 16;43(3):609-16. doi: 10.1111/j.1432-1033.1974.tb03448.x.
5
L-serine dehydratase and L-serine-pyruvate aminotransferase activities in different animal species.不同动物物种中L-丝氨酸脱水酶和L-丝氨酸-丙酮酸转氨酶的活性。
Comp Biochem Physiol B. 1979;63(4):543-55. doi: 10.1016/0305-0491(79)90061-0.
6
Increase of L-serine dehydratase activity under gluconeogenic conditions in adult-rat hepatocytes cultured on collagen gel/nylon mesh.在胶原凝胶/尼龙网上培养的成年大鼠肝细胞中,糖异生条件下L-丝氨酸脱水酶活性的增加。
Biochem J. 1981 Sep 15;198(3):499-504. doi: 10.1042/bj1980499.
7
[The key enzymes of the alternative pathways of serine utilization in gluconeogenesis in chickens during individual development].[鸡个体发育过程中糖异生作用中丝氨酸利用替代途径的关键酶]
Zh Evol Biokhim Fiziol. 1990 May-Jun;26(3):424-6.
8
Enzymes of serine metabolism in normal, developing and neoplastic rat tissues.正常、发育中和肿瘤大鼠组织中丝氨酸代谢的酶
Adv Enzyme Regul. 1984;22:325-400. doi: 10.1016/0065-2571(84)90021-9.
9
Dietary and hormonal regulation of hepatic biosynthetic and catabolic enzymes of serine metabolism in rats.大鼠丝氨酸代谢中肝脏生物合成和分解代谢酶的饮食和激素调节
Endocrinology. 1972 Oct;91(4):1054-63. doi: 10.1210/endo-91-4-1054.
10
Liver enzymes of serine metabolism during neonatal development of the rat.大鼠新生儿发育过程中丝氨酸代谢的肝脏酶
Biochem J. 1980 Aug 15;190(2):451-5. doi: 10.1042/bj1900451.

引用本文的文献

1
Metabolic signatures and risk of type 2 diabetes in a Chinese population: an untargeted metabolomics study using both LC-MS and GC-MS.中国人群中2型糖尿病的代谢特征与风险:一项使用液相色谱-质谱联用仪和气相色谱-质谱联用仪的非靶向代谢组学研究
Diabetologia. 2016 Nov;59(11):2349-2359. doi: 10.1007/s00125-016-4069-2. Epub 2016 Aug 11.
2
Studies on a unique organelle localization of a liver enzyme, serine:pyruvate (or alanine:glyoxylate) aminotransferase.研究一种肝脏酶——丝氨酸:丙酮酸(或丙氨酸:乙醛酸)氨基转移酶的独特细胞器定位。
Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(5):274-86. doi: 10.2183/pjab.87.274.
3
Increase of L-serine dehydratase activity under gluconeogenic conditions in adult-rat hepatocytes cultured on collagen gel/nylon mesh.在胶原凝胶/尼龙网上培养的成年大鼠肝细胞中,糖异生条件下L-丝氨酸脱水酶活性的增加。
Biochem J. 1981 Sep 15;198(3):499-504. doi: 10.1042/bj1980499.
4
The subcellular distribution of rat liver serine-pyruvate aminotransferase.大鼠肝脏丝氨酸 - 丙酮酸氨基转移酶的亚细胞分布
Biochem J. 1982 Feb 15;202(2):483-90. doi: 10.1042/bj2020483.
5
Liver enzymes of serine metabolism during neonatal development of the rat.大鼠新生儿发育过程中丝氨酸代谢的肝脏酶
Biochem J. 1980 Aug 15;190(2):451-5. doi: 10.1042/bj1900451.
6
Immunoelectron microscopic localization of serine: pyruvate aminotransferase in rat eosinophile leukocytes.大鼠嗜酸性粒细胞中丝氨酸:丙酮酸氨基转移酶的免疫电子显微镜定位
Histochemistry. 1983;78(4):417-24. doi: 10.1007/BF00496193.
7
Polyamine and amino acid content, and activity of polyamine-synthesizing decarboxylases, in liver of streptozotocin-induced diabetic and insulin-treated diabetic rats.链脲佐菌素诱导的糖尿病大鼠及胰岛素治疗的糖尿病大鼠肝脏中的多胺和氨基酸含量以及多胺合成脱羧酶的活性
Biochem J. 1980 Aug 15;190(2):395-403. doi: 10.1042/bj1900395.
8
Pathways of gluconeogenesis from L-serine in the neonatal rat.新生大鼠中由L-丝氨酸生成葡萄糖的途径。
Biochem J. 1974 Aug;142(2):433-6. doi: 10.1042/bj1420433.
9
Regulation of hepatic L-serine dehydratase and L-serine-pyruvate aminotransferase in the developing neonatal rat.新生大鼠发育过程中肝脏L-丝氨酸脱水酶和L-丝氨酸-丙酮酸转氨酶的调节
Biochem J. 1974 Dec;144(3):519-31. doi: 10.1042/bj1440519.
10
Quantitative immunocytochemical studies on differential induction of serine:pyruvate aminotransferase in mitochondria and peroxisomes of rat liver cells by administration of glucagon or di-(2-ethylhexyl)phthalate.关于通过给予胰高血糖素或邻苯二甲酸二(2-乙基己基)酯对大鼠肝细胞线粒体和过氧化物酶体中丝氨酸:丙酮酸氨基转移酶进行差异诱导的定量免疫细胞化学研究。
Histochemistry. 1986;85(2):145-55. doi: 10.1007/BF00491762.

本文引用的文献

1
Development of gluconeogenesis in neonatal rat liver. Effect of premature delivery.新生大鼠肝糖异生的发育。早产的影响。
Biochem J. 1967 Dec;105(3):1229-33. doi: 10.1042/bj1051229.
2
CARBOHYDRATE METABOLISM IN LIVER FROM FOETAL AND NEONATAL SHEEP.胎儿和新生绵羊肝脏中的碳水化合物代谢
Biochem J. 1965 Apr;95(1):191-200. doi: 10.1042/bj0950191.
3
HORMONAL AND DIETARY CONTROL OF SERINE DEHYDRATASE IN RAT LIVER.大鼠肝脏中丝氨酸脱水酶的激素和饮食调控
J Biochem. 1965 Apr;57:506-13. doi: 10.1093/oxfordjournals.jbchem.a128109.
4
CHANGES IN THE ACTIVITIES OF D-GLYCERATE AND D-3-PHOSPHOGLYCERATE DEHYDROGENASES IN THE DEVELOPING RAT LIVER.发育中大鼠肝脏中D-甘油酸脱氢酶和D-3-磷酸甘油酸脱氢酶活性的变化
Biochim Biophys Acta. 1964 May 4;85:202-5. doi: 10.1016/0926-6569(64)90241-x.
5
Studies on the metabolism of hydroxypyruvate in animal tissues.动物组织中羟基丙酮酸代谢的研究。
Biochem J. 1959 Jul;72(3):496-508. doi: 10.1042/bj0720496.
6
Metabolism of D- and L-[3-14C]glycerate by liver tissue of the rat.大鼠肝脏组织对D-和L-[3-14C]甘油酸的代谢
Biochem J. 1960 Nov;77(2):356-63. doi: 10.1042/bj0770356.
7
[Isolation of D-glycerate dehydrogenase, some properties of the enzyme and its application to the enzymic-optic determination of hydroxypyruvate in presence of pyruvate].[D-甘油酸脱氢酶的分离、该酶的某些性质及其在丙酮酸存在下用于羟基丙酮酸的酶促-光学测定中的应用]
Biochem Z. 1957;329(4):292-312.
8
Gluconeogenesis from amino acids in neonatal rat liver.新生大鼠肝脏中氨基酸的糖异生作用。
Biochem J. 1967 Jun;103(3):744-8. doi: 10.1042/bj1030744.
9
Carbohydrate formation from various precursors in noenatal rat liver.新生大鼠肝脏中由各种前体物质形成碳水化合物的过程。
Biochem J. 1968 Dec;110(4):725-31. doi: 10.1042/bj1100725.
10
Liver-L-alanine-glyoxylate and L-serine-pyruvate aminotransferase activities: an apparent association with gluconeogenesis.肝脏L-丙氨酸-乙醛酸和L-丝氨酸-丙酮酸转氨酶活性:与糖异生的明显关联。
Biochem J. 1969 Dec;115(5):1071-3. doi: 10.1042/bj1151071.