钩端螺旋体病期间动物血液和血浆中的细胞毒性因子。
Cytotoxic factor in the blood and plasma of animals during leptospirosis.
作者信息
Knight L L, Miller N G, White R J
出版信息
Infect Immun. 1973 Sep;8(3):401-5. doi: 10.1128/iai.8.3.401-405.1973.
Abstract
Whole blood and plasma from animals in the acute stage of leptospirosis contained a toxic factor which produced a cytopathic effect on fibroblastic L cell monolayers. Firm adsorption of cytotoxic factor (CTF) to L cells occurred within 1 h. The highest titer of CTF in plasma was reached at 24 h and declined after 48 h after the inoculation of leptospires. Toxic effects were also obtained with intracerebral inoculation of mice with plasma containing CTF. Mice showed signs of motor instability and muscular spasms shortly after inoculation with CTF. Death usually occurred within 1 h.
摘要
钩端螺旋体病急性期动物的全血和血浆含有一种毒性因子，该因子对成纤维细胞L细胞单层产生细胞病变效应。细胞毒性因子（CTF）在1小时内牢固吸附于L细胞。接种钩端螺旋体后24小时血浆中CTF滴度达到最高，48小时后下降。用含CTF的血浆脑内接种小鼠也可产生毒性作用。小鼠接种CTF后不久即出现运动不稳和肌肉痉挛症状。通常在1小时内死亡。
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